Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

Axial length is the primary determinant of eye size, and it is elongated in myopia. However, the underlying mechanism of the onset and progression of axial elongation remain unclear. Here, we show that endoplasmic reticulum (ER) stress in sclera is an essential regulator of axial elongation in myopi...

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Detalles Bibliográficos
Autores principales: Ikeda, Shin-ichi, Kurihara, Toshihide, Jiang, Xiaoyan, Miwa, Yukihiro, Lee, Deokho, Serizawa, Naho, Jeong, Heonuk, Mori, Kiwako, Katada, Yusaku, Kunimi, Hiromitsu, Ozawa, Nobuhiro, Shoda, Chiho, Ibuki, Mari, Negishi, Kazuno, Torii, Hidemasa, Tsubota, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550863/
https://www.ncbi.nlm.nih.gov/pubmed/36216837
http://dx.doi.org/10.1038/s41467-022-33605-1

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