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The role of circadian rhythm in osteoporosis; a review
Osteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and di...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550872/ https://www.ncbi.nlm.nih.gov/pubmed/36238690 http://dx.doi.org/10.3389/fcell.2022.960456 |
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author | Tian, Yihao Ming, Jian |
author_facet | Tian, Yihao Ming, Jian |
author_sort | Tian, Yihao |
collection | PubMed |
description | Osteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and differentiation, and inhibiting osteoclast differentiation. Specifically, in vivo mechanisms are initiated by stabilizing biological rhythms in bone tissue. In healthy organisms, these biological rhythms are present in bone tissue, and are characterized by bone formation during the day, and bone resorption at night. When this rhythm is disrupted, osteoporosis occurs. Thus, taking appropriate medication at different times of the day could produce different effects on osteoporosis rhythms. In this review, we characterized these processes, and provided treatments and management strategies for individuals with osteoporosis. |
format | Online Article Text |
id | pubmed-9550872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95508722022-10-12 The role of circadian rhythm in osteoporosis; a review Tian, Yihao Ming, Jian Front Cell Dev Biol Cell and Developmental Biology Osteoporosis is characterized by a high incidence rate, with significant effects on people’s lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and differentiation, and inhibiting osteoclast differentiation. Specifically, in vivo mechanisms are initiated by stabilizing biological rhythms in bone tissue. In healthy organisms, these biological rhythms are present in bone tissue, and are characterized by bone formation during the day, and bone resorption at night. When this rhythm is disrupted, osteoporosis occurs. Thus, taking appropriate medication at different times of the day could produce different effects on osteoporosis rhythms. In this review, we characterized these processes, and provided treatments and management strategies for individuals with osteoporosis. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9550872/ /pubmed/36238690 http://dx.doi.org/10.3389/fcell.2022.960456 Text en Copyright © 2022 Tian and Ming. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Tian, Yihao Ming, Jian The role of circadian rhythm in osteoporosis; a review |
title | The role of circadian rhythm in osteoporosis; a review |
title_full | The role of circadian rhythm in osteoporosis; a review |
title_fullStr | The role of circadian rhythm in osteoporosis; a review |
title_full_unstemmed | The role of circadian rhythm in osteoporosis; a review |
title_short | The role of circadian rhythm in osteoporosis; a review |
title_sort | role of circadian rhythm in osteoporosis; a review |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550872/ https://www.ncbi.nlm.nih.gov/pubmed/36238690 http://dx.doi.org/10.3389/fcell.2022.960456 |
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