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Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition
Recent investigations have raised the question of the role of the anterior lateral temporal cortex in language processing (ventral language network). Here we present the language and overall cognitive performance of a rare male patient with chronic middle cerebral artery cerebrovascular accident wit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551096/ https://www.ncbi.nlm.nih.gov/pubmed/36217017 http://dx.doi.org/10.1038/s42003-022-03983-9 |
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author | Kourtidou, Evie Kasselimis, Dimitrios Angelopoulou, Georgia Karavasilis, Efstratios Velonakis, Georgios Kelekis, Nikolaos Zalonis, Ioannis Evdokimidis, Ioannis Potagas, Constantin Petrides, Michael |
author_facet | Kourtidou, Evie Kasselimis, Dimitrios Angelopoulou, Georgia Karavasilis, Efstratios Velonakis, Georgios Kelekis, Nikolaos Zalonis, Ioannis Evdokimidis, Ioannis Potagas, Constantin Petrides, Michael |
author_sort | Kourtidou, Evie |
collection | PubMed |
description | Recent investigations have raised the question of the role of the anterior lateral temporal cortex in language processing (ventral language network). Here we present the language and overall cognitive performance of a rare male patient with chronic middle cerebral artery cerebrovascular accident with a well-documented lesion restricted to the anterior temporal cortex and its connections via the extreme capsule with the pars triangularis of the inferior frontal gyrus (i.e. Broca’s region). The performance of this unique patient is compared with that of two chronic middle cerebral artery cerebrovascular accident male patients with damage to the classic dorsal posterior temporo-parietal language system. Diffusion tensor imaging is used to reconstruct the relevant white matter tracts of the three patients, which are also compared with those of 10 healthy individuals. The patient with the anterior temporo-frontal lesion presents with flawless and fluent speech, but selective impairment in accessing lexico-semantic information, in sharp contrast to the impairments in speech, sentence comprehension and repetition observed after lesions to the classic dorsal language system. The present results underline the contribution of the ventral language stream in lexico-semantic processing and higher cognitive functions, such as active selective controlled retrieval. |
format | Online Article Text |
id | pubmed-9551096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95510962022-10-12 Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition Kourtidou, Evie Kasselimis, Dimitrios Angelopoulou, Georgia Karavasilis, Efstratios Velonakis, Georgios Kelekis, Nikolaos Zalonis, Ioannis Evdokimidis, Ioannis Potagas, Constantin Petrides, Michael Commun Biol Article Recent investigations have raised the question of the role of the anterior lateral temporal cortex in language processing (ventral language network). Here we present the language and overall cognitive performance of a rare male patient with chronic middle cerebral artery cerebrovascular accident with a well-documented lesion restricted to the anterior temporal cortex and its connections via the extreme capsule with the pars triangularis of the inferior frontal gyrus (i.e. Broca’s region). The performance of this unique patient is compared with that of two chronic middle cerebral artery cerebrovascular accident male patients with damage to the classic dorsal posterior temporo-parietal language system. Diffusion tensor imaging is used to reconstruct the relevant white matter tracts of the three patients, which are also compared with those of 10 healthy individuals. The patient with the anterior temporo-frontal lesion presents with flawless and fluent speech, but selective impairment in accessing lexico-semantic information, in sharp contrast to the impairments in speech, sentence comprehension and repetition observed after lesions to the classic dorsal language system. The present results underline the contribution of the ventral language stream in lexico-semantic processing and higher cognitive functions, such as active selective controlled retrieval. Nature Publishing Group UK 2022-10-10 /pmc/articles/PMC9551096/ /pubmed/36217017 http://dx.doi.org/10.1038/s42003-022-03983-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kourtidou, Evie Kasselimis, Dimitrios Angelopoulou, Georgia Karavasilis, Efstratios Velonakis, Georgios Kelekis, Nikolaos Zalonis, Ioannis Evdokimidis, Ioannis Potagas, Constantin Petrides, Michael Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
title | Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
title_full | Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
title_fullStr | Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
title_full_unstemmed | Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
title_short | Specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
title_sort | specific disruption of the ventral anterior temporo-frontal network reveals key implications for language comprehension and cognition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551096/ https://www.ncbi.nlm.nih.gov/pubmed/36217017 http://dx.doi.org/10.1038/s42003-022-03983-9 |
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