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Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis

BACKGROUND AND OBJECTIVE: Vaccine uptake rates during pregnancy remain below target goals due to a convergence of factors. In particular, women of lower socioeconomic means and racial minorities typically have reduced rates of vaccine acceptance. This study aims to identify additional factors contri...

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Autores principales: Coleman, Maame Aba, Dongarwar, Deepa, Ramirez, Jessica, Laracuente, Mei-Li, Livingston, Chelsea, Ogu, Julliet, Lyn, Racquel, Hall, Arabella, Adu-Gyamfi, Sylvia, Salihu, Hamisu M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Global Health and Education Projects, Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551120/
https://www.ncbi.nlm.nih.gov/pubmed/36258713
http://dx.doi.org/10.21106/ijma.554
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author Coleman, Maame Aba
Dongarwar, Deepa
Ramirez, Jessica
Laracuente, Mei-Li
Livingston, Chelsea
Ogu, Julliet
Lyn, Racquel
Hall, Arabella
Adu-Gyamfi, Sylvia
Salihu, Hamisu M.
author_facet Coleman, Maame Aba
Dongarwar, Deepa
Ramirez, Jessica
Laracuente, Mei-Li
Livingston, Chelsea
Ogu, Julliet
Lyn, Racquel
Hall, Arabella
Adu-Gyamfi, Sylvia
Salihu, Hamisu M.
author_sort Coleman, Maame Aba
collection PubMed
description BACKGROUND AND OBJECTIVE: Vaccine uptake rates during pregnancy remain below target goals due to a convergence of factors. In particular, women of lower socioeconomic means and racial minorities typically have reduced rates of vaccine acceptance. This study aims to identify additional factors contributing to vaccine acceptance within a sample population of women receiving prenatal care in Houston, Texas, United States of America. METHODS: We performed a retrospective cross-sectional analysis of 11,500 pregnant women covered by Medicaid or ChipPerinate who received prenatal care during 2013-2021, assessing influenza (flu) and combined Tetanus, Diphtheria, Acellular Pertussis (TDAP) vaccine acceptance in the patient population. We examined temporal trends in flu and TDAP vaccination rates using Joinpoint regression analyses and evaluated the factors associated with single or concomitant vaccine acceptance during the study period and during the COVID-19 pandemic using adjusted log-binomial regression models. RESULTS: In our population, 54% of patients received flu vaccination, and 76.1% received TDAP. TDAP rates increased from 2013-2015 but have shown an overall decline since then, as with the flu vaccine. Earlier entry to prenatal care (Prevalence Ratio [PR] 6.32; Confidence Interval [CI] 3.28-12.24) and pregnancy comorbidity such as gestational diabetes (PR 1.32; CI 0.82-2.19) were positively associated with uptake. In contrast, the NH-Black race was negatively associated with vaccine acceptance (PR 0.51 CI; 0.25-0.99). Otherwise, age and history of pre-pregnancy comorbidities were not significant predictors. CONCLUSION AND GLOBAL HEALTH IMPLICATIONS: Within demographic groups identified as at-risk for vaccine refusal, modifying factors further impact vaccine hesitancy. Identifying these elements will guide targeted patient efforts to promote vaccine uptake, both for routine prenatal recommendations and for COVID vaccination.
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spelling pubmed-95511202022-10-17 Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis Coleman, Maame Aba Dongarwar, Deepa Ramirez, Jessica Laracuente, Mei-Li Livingston, Chelsea Ogu, Julliet Lyn, Racquel Hall, Arabella Adu-Gyamfi, Sylvia Salihu, Hamisu M. Int J MCH AIDS Original Article | Vaccine BACKGROUND AND OBJECTIVE: Vaccine uptake rates during pregnancy remain below target goals due to a convergence of factors. In particular, women of lower socioeconomic means and racial minorities typically have reduced rates of vaccine acceptance. This study aims to identify additional factors contributing to vaccine acceptance within a sample population of women receiving prenatal care in Houston, Texas, United States of America. METHODS: We performed a retrospective cross-sectional analysis of 11,500 pregnant women covered by Medicaid or ChipPerinate who received prenatal care during 2013-2021, assessing influenza (flu) and combined Tetanus, Diphtheria, Acellular Pertussis (TDAP) vaccine acceptance in the patient population. We examined temporal trends in flu and TDAP vaccination rates using Joinpoint regression analyses and evaluated the factors associated with single or concomitant vaccine acceptance during the study period and during the COVID-19 pandemic using adjusted log-binomial regression models. RESULTS: In our population, 54% of patients received flu vaccination, and 76.1% received TDAP. TDAP rates increased from 2013-2015 but have shown an overall decline since then, as with the flu vaccine. Earlier entry to prenatal care (Prevalence Ratio [PR] 6.32; Confidence Interval [CI] 3.28-12.24) and pregnancy comorbidity such as gestational diabetes (PR 1.32; CI 0.82-2.19) were positively associated with uptake. In contrast, the NH-Black race was negatively associated with vaccine acceptance (PR 0.51 CI; 0.25-0.99). Otherwise, age and history of pre-pregnancy comorbidities were not significant predictors. CONCLUSION AND GLOBAL HEALTH IMPLICATIONS: Within demographic groups identified as at-risk for vaccine refusal, modifying factors further impact vaccine hesitancy. Identifying these elements will guide targeted patient efforts to promote vaccine uptake, both for routine prenatal recommendations and for COVID vaccination. Global Health and Education Projects, Inc 2022 2022-09-07 /pmc/articles/PMC9551120/ /pubmed/36258713 http://dx.doi.org/10.21106/ijma.554 Text en Copyright © 2022 Stokes et al. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article | Vaccine
Coleman, Maame Aba
Dongarwar, Deepa
Ramirez, Jessica
Laracuente, Mei-Li
Livingston, Chelsea
Ogu, Julliet
Lyn, Racquel
Hall, Arabella
Adu-Gyamfi, Sylvia
Salihu, Hamisu M.
Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis
title Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis
title_full Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis
title_fullStr Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis
title_full_unstemmed Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis
title_short Factors Impacting Vaccine Uptake during Pregnancy: A Retrospective Analysis
title_sort factors impacting vaccine uptake during pregnancy: a retrospective analysis
topic Original Article | Vaccine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551120/
https://www.ncbi.nlm.nih.gov/pubmed/36258713
http://dx.doi.org/10.21106/ijma.554
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