CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis

BACKGROUND: Circular RNAs (circRNAs) are implicated in carcinogenesis, including papillary thyroid cancer (PTC). Despite of previous reports regarding the high expression of circPTPRM in PTC, the role and regulatory mechanism remain to be investigated. METHODS: CircPTPRM and miR‐885‐5p expression we...

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Autores principales: Chen, Daping, Jiang, Xijiao, Luo, Huizhou, Hua, Qingquan, Zhang, Farong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551131/
https://www.ncbi.nlm.nih.gov/pubmed/36098040
http://dx.doi.org/10.1002/jcla.24688
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author Chen, Daping
Jiang, Xijiao
Luo, Huizhou
Hua, Qingquan
Zhang, Farong
author_facet Chen, Daping
Jiang, Xijiao
Luo, Huizhou
Hua, Qingquan
Zhang, Farong
author_sort Chen, Daping
collection PubMed
description BACKGROUND: Circular RNAs (circRNAs) are implicated in carcinogenesis, including papillary thyroid cancer (PTC). Despite of previous reports regarding the high expression of circPTPRM in PTC, the role and regulatory mechanism remain to be investigated. METHODS: CircPTPRM and miR‐885‐5p expression were examined, and the effects on cell proliferation, migration, and invasion were also measured. Immunoblotting was performed to evaluate DNA methyltransferase 3A (DNMT3A) and the epithelial‐mesenchymal transition (EMT)‐associated proteins. RESULTS: CircPTPRM was overexpressed in PTC tissues and cell lines, which predicted poor prognosis. CircPTPRM inhibition significantly alleviated the proliferation, migration, and invasion abilities. It was subsequently confirmed that circPTPRM competed with miR‐885‐5p for DNMT3A binding. CircPTPRM promoted PTC progression via miR‐885‐5p/DNMT3A signal axis. CONCLUSION: Our data elucidated that circPTPRM may play an oncogenic role in PTC through circPTPRM/miR‐885‐5p/DNMT3A axis
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spelling pubmed-95511312022-10-14 CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis Chen, Daping Jiang, Xijiao Luo, Huizhou Hua, Qingquan Zhang, Farong J Clin Lab Anal Research Articles BACKGROUND: Circular RNAs (circRNAs) are implicated in carcinogenesis, including papillary thyroid cancer (PTC). Despite of previous reports regarding the high expression of circPTPRM in PTC, the role and regulatory mechanism remain to be investigated. METHODS: CircPTPRM and miR‐885‐5p expression were examined, and the effects on cell proliferation, migration, and invasion were also measured. Immunoblotting was performed to evaluate DNA methyltransferase 3A (DNMT3A) and the epithelial‐mesenchymal transition (EMT)‐associated proteins. RESULTS: CircPTPRM was overexpressed in PTC tissues and cell lines, which predicted poor prognosis. CircPTPRM inhibition significantly alleviated the proliferation, migration, and invasion abilities. It was subsequently confirmed that circPTPRM competed with miR‐885‐5p for DNMT3A binding. CircPTPRM promoted PTC progression via miR‐885‐5p/DNMT3A signal axis. CONCLUSION: Our data elucidated that circPTPRM may play an oncogenic role in PTC through circPTPRM/miR‐885‐5p/DNMT3A axis John Wiley and Sons Inc. 2022-09-13 /pmc/articles/PMC9551131/ /pubmed/36098040 http://dx.doi.org/10.1002/jcla.24688 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Chen, Daping
Jiang, Xijiao
Luo, Huizhou
Hua, Qingquan
Zhang, Farong
CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis
title CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis
title_full CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis
title_fullStr CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis
title_full_unstemmed CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis
title_short CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis
title_sort circptprm accelerates malignancy of papillary thyroid cancer via mir‐885‐5p/dnmt3a axis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551131/
https://www.ncbi.nlm.nih.gov/pubmed/36098040
http://dx.doi.org/10.1002/jcla.24688
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