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The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis

Sepsis is a life-threatening dysregulated host response to infection that compromises organ health, and abdominal sepsis is a commonly presenting critical illness in intensive care units (ICU). In this study, we investigate the effect of age on clinical sepsis characteristics and innate immune cells...

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Autores principales: Lu, Jiaqi, Liu, Jingyuan, Zhu, Liuluan, Zhang, Yue, Li, Ang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551265/
https://www.ncbi.nlm.nih.gov/pubmed/36237524
http://dx.doi.org/10.3389/fphys.2022.952434
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author Lu, Jiaqi
Liu, Jingyuan
Zhu, Liuluan
Zhang, Yue
Li, Ang
author_facet Lu, Jiaqi
Liu, Jingyuan
Zhu, Liuluan
Zhang, Yue
Li, Ang
author_sort Lu, Jiaqi
collection PubMed
description Sepsis is a life-threatening dysregulated host response to infection that compromises organ health, and abdominal sepsis is a commonly presenting critical illness in intensive care units (ICU). In this study, we investigate the effect of age on clinical sepsis characteristics and innate immune cells (neutrophils and monocytes) functionality in abdominal sepsis patients. We recruited 32 patients with abdominal sepsis from the Beijing Ditan Hospital’s ICU from February 2021 to September 2021, and selected 18 healthy volunteers that were age- and sex-matched as controls for a prospective cohort study. Elderly abdominal sepsis patients (age >65 years) had the following altered characteristics compared to nonelderly patient controls: lower mean arterial pressure, monocytes percentage, and red blood cell volume distribution width (p < 0.05); higher neutrophils percentage and neutrophils-to-lymphocytes ratio (p < 0.05); significantly increased monocyte-produced reactive oxygen (p < 0.05); increases neutrophilic secretion of TNF-α, as well as lower monocytic secretion of TNF-α (p < 0.05); higher neutrophil percentage (which was significantly higher in peripheral blood than monocyte percentage). Elderly patients also had significantly increased phagocytic activity in their neutrophils and monocytes (p < 0.05), significantly reduced neutrophils-produced reactive oxygen (p < 0.001), and significantly increased TNF-α secretion by monocytes and neutrophils (p < 0.05). We found that elderly patients have decreased immune cell function and increased release of cytokines compared to younger patients, suggesting individualized treatment plans targeting the elderly septic microenvironment could help prevent organ failure in elderly septic patients and improves patient survival.
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spelling pubmed-95512652022-10-12 The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis Lu, Jiaqi Liu, Jingyuan Zhu, Liuluan Zhang, Yue Li, Ang Front Physiol Physiology Sepsis is a life-threatening dysregulated host response to infection that compromises organ health, and abdominal sepsis is a commonly presenting critical illness in intensive care units (ICU). In this study, we investigate the effect of age on clinical sepsis characteristics and innate immune cells (neutrophils and monocytes) functionality in abdominal sepsis patients. We recruited 32 patients with abdominal sepsis from the Beijing Ditan Hospital’s ICU from February 2021 to September 2021, and selected 18 healthy volunteers that were age- and sex-matched as controls for a prospective cohort study. Elderly abdominal sepsis patients (age >65 years) had the following altered characteristics compared to nonelderly patient controls: lower mean arterial pressure, monocytes percentage, and red blood cell volume distribution width (p < 0.05); higher neutrophils percentage and neutrophils-to-lymphocytes ratio (p < 0.05); significantly increased monocyte-produced reactive oxygen (p < 0.05); increases neutrophilic secretion of TNF-α, as well as lower monocytic secretion of TNF-α (p < 0.05); higher neutrophil percentage (which was significantly higher in peripheral blood than monocyte percentage). Elderly patients also had significantly increased phagocytic activity in their neutrophils and monocytes (p < 0.05), significantly reduced neutrophils-produced reactive oxygen (p < 0.001), and significantly increased TNF-α secretion by monocytes and neutrophils (p < 0.05). We found that elderly patients have decreased immune cell function and increased release of cytokines compared to younger patients, suggesting individualized treatment plans targeting the elderly septic microenvironment could help prevent organ failure in elderly septic patients and improves patient survival. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9551265/ /pubmed/36237524 http://dx.doi.org/10.3389/fphys.2022.952434 Text en Copyright © 2022 Lu, Liu, Zhu, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Lu, Jiaqi
Liu, Jingyuan
Zhu, Liuluan
Zhang, Yue
Li, Ang
The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
title The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
title_full The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
title_fullStr The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
title_full_unstemmed The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
title_short The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
title_sort effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551265/
https://www.ncbi.nlm.nih.gov/pubmed/36237524
http://dx.doi.org/10.3389/fphys.2022.952434
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