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The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis
Sepsis is a life-threatening dysregulated host response to infection that compromises organ health, and abdominal sepsis is a commonly presenting critical illness in intensive care units (ICU). In this study, we investigate the effect of age on clinical sepsis characteristics and innate immune cells...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551265/ https://www.ncbi.nlm.nih.gov/pubmed/36237524 http://dx.doi.org/10.3389/fphys.2022.952434 |
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author | Lu, Jiaqi Liu, Jingyuan Zhu, Liuluan Zhang, Yue Li, Ang |
author_facet | Lu, Jiaqi Liu, Jingyuan Zhu, Liuluan Zhang, Yue Li, Ang |
author_sort | Lu, Jiaqi |
collection | PubMed |
description | Sepsis is a life-threatening dysregulated host response to infection that compromises organ health, and abdominal sepsis is a commonly presenting critical illness in intensive care units (ICU). In this study, we investigate the effect of age on clinical sepsis characteristics and innate immune cells (neutrophils and monocytes) functionality in abdominal sepsis patients. We recruited 32 patients with abdominal sepsis from the Beijing Ditan Hospital’s ICU from February 2021 to September 2021, and selected 18 healthy volunteers that were age- and sex-matched as controls for a prospective cohort study. Elderly abdominal sepsis patients (age >65 years) had the following altered characteristics compared to nonelderly patient controls: lower mean arterial pressure, monocytes percentage, and red blood cell volume distribution width (p < 0.05); higher neutrophils percentage and neutrophils-to-lymphocytes ratio (p < 0.05); significantly increased monocyte-produced reactive oxygen (p < 0.05); increases neutrophilic secretion of TNF-α, as well as lower monocytic secretion of TNF-α (p < 0.05); higher neutrophil percentage (which was significantly higher in peripheral blood than monocyte percentage). Elderly patients also had significantly increased phagocytic activity in their neutrophils and monocytes (p < 0.05), significantly reduced neutrophils-produced reactive oxygen (p < 0.001), and significantly increased TNF-α secretion by monocytes and neutrophils (p < 0.05). We found that elderly patients have decreased immune cell function and increased release of cytokines compared to younger patients, suggesting individualized treatment plans targeting the elderly septic microenvironment could help prevent organ failure in elderly septic patients and improves patient survival. |
format | Online Article Text |
id | pubmed-9551265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95512652022-10-12 The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis Lu, Jiaqi Liu, Jingyuan Zhu, Liuluan Zhang, Yue Li, Ang Front Physiol Physiology Sepsis is a life-threatening dysregulated host response to infection that compromises organ health, and abdominal sepsis is a commonly presenting critical illness in intensive care units (ICU). In this study, we investigate the effect of age on clinical sepsis characteristics and innate immune cells (neutrophils and monocytes) functionality in abdominal sepsis patients. We recruited 32 patients with abdominal sepsis from the Beijing Ditan Hospital’s ICU from February 2021 to September 2021, and selected 18 healthy volunteers that were age- and sex-matched as controls for a prospective cohort study. Elderly abdominal sepsis patients (age >65 years) had the following altered characteristics compared to nonelderly patient controls: lower mean arterial pressure, monocytes percentage, and red blood cell volume distribution width (p < 0.05); higher neutrophils percentage and neutrophils-to-lymphocytes ratio (p < 0.05); significantly increased monocyte-produced reactive oxygen (p < 0.05); increases neutrophilic secretion of TNF-α, as well as lower monocytic secretion of TNF-α (p < 0.05); higher neutrophil percentage (which was significantly higher in peripheral blood than monocyte percentage). Elderly patients also had significantly increased phagocytic activity in their neutrophils and monocytes (p < 0.05), significantly reduced neutrophils-produced reactive oxygen (p < 0.001), and significantly increased TNF-α secretion by monocytes and neutrophils (p < 0.05). We found that elderly patients have decreased immune cell function and increased release of cytokines compared to younger patients, suggesting individualized treatment plans targeting the elderly septic microenvironment could help prevent organ failure in elderly septic patients and improves patient survival. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9551265/ /pubmed/36237524 http://dx.doi.org/10.3389/fphys.2022.952434 Text en Copyright © 2022 Lu, Liu, Zhu, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Lu, Jiaqi Liu, Jingyuan Zhu, Liuluan Zhang, Yue Li, Ang The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
title | The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
title_full | The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
title_fullStr | The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
title_full_unstemmed | The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
title_short | The effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
title_sort | effect of age on the clinical characteristics and innate immune cell function in the patients with abdominal sepsis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551265/ https://www.ncbi.nlm.nih.gov/pubmed/36237524 http://dx.doi.org/10.3389/fphys.2022.952434 |
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