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Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo

During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migration being one of the most common. As cells migrate, they squeeze through crowded microenvironments to reach the positions where they ultimately execute their function. Much of our...

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Autores principales: Ventura, Guilherme, Sedzinski, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551290/
https://www.ncbi.nlm.nih.gov/pubmed/36238689
http://dx.doi.org/10.3389/fcell.2022.961460
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author Ventura, Guilherme
Sedzinski, Jakub
author_facet Ventura, Guilherme
Sedzinski, Jakub
author_sort Ventura, Guilherme
collection PubMed
description During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migration being one of the most common. As cells migrate, they squeeze through crowded microenvironments to reach the positions where they ultimately execute their function. Much of our knowledge of cell migration has been based on cells’ ability to navigate in vitro and how cells respond to the mechanical properties of the extracellular matrix (ECM). These simplified and largely passive surroundings contrast with the complexity of the tissue environments in vivo, where different cells and ECM make up the milieu cells migrate in. Due to this complexity, comparatively little is known about how the physical interactions between migrating cells and their tissue environment instruct cell movement in vivo. Work in different model organisms has been instrumental in addressing this question. Here, we explore various examples of cell migration in vivo and describe how the physical interplay between migrating cells and the neighboring microenvironment controls cell behavior. Understanding this mechanical cooperation in vivo will provide key insights into organ development, regeneration, and disease.
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spelling pubmed-95512902022-10-12 Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo Ventura, Guilherme Sedzinski, Jakub Front Cell Dev Biol Cell and Developmental Biology During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migration being one of the most common. As cells migrate, they squeeze through crowded microenvironments to reach the positions where they ultimately execute their function. Much of our knowledge of cell migration has been based on cells’ ability to navigate in vitro and how cells respond to the mechanical properties of the extracellular matrix (ECM). These simplified and largely passive surroundings contrast with the complexity of the tissue environments in vivo, where different cells and ECM make up the milieu cells migrate in. Due to this complexity, comparatively little is known about how the physical interactions between migrating cells and their tissue environment instruct cell movement in vivo. Work in different model organisms has been instrumental in addressing this question. Here, we explore various examples of cell migration in vivo and describe how the physical interplay between migrating cells and the neighboring microenvironment controls cell behavior. Understanding this mechanical cooperation in vivo will provide key insights into organ development, regeneration, and disease. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9551290/ /pubmed/36238689 http://dx.doi.org/10.3389/fcell.2022.961460 Text en Copyright © 2022 Ventura and Sedzinski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ventura, Guilherme
Sedzinski, Jakub
Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
title Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
title_full Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
title_fullStr Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
title_full_unstemmed Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
title_short Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
title_sort emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551290/
https://www.ncbi.nlm.nih.gov/pubmed/36238689
http://dx.doi.org/10.3389/fcell.2022.961460
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