APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress

Polymorphisms in the Apolipoprotein L1 (APOL1) gene are common in ancestrally African populations, and associate with kidney injury and cardiovascular disease. These risk variants (RV) provide an advantage in resisting Trypanosoma brucei, the causal agent of African trypanosomiasis, and are largely...

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Detalles Bibliográficos
Autores principales: Blazer, Ashira, Qian, Yingzhi, Schlegel, Martin Paul, Algasas, Huda, Buyon, Jill P., Cadwell, Ken, Cammer, Michael, Heffron, Sean P., Liang, Feng-Xia, Mehta-Lee, Shilpi, Niewold, Timothy, Rasmussen, Sara E., Clancy, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551299/
https://www.ncbi.nlm.nih.gov/pubmed/36238153
http://dx.doi.org/10.3389/fgene.2022.769936

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