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Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway

OBJECTIVE: To investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells. METHODS: A high-fat diet-induced hyperinsulinemia model in ZDF rats wa...

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Detalles Bibliográficos
Autores principales:	Xie, Jinlan, Zhong, Feifei, Guo, Zhenhong, Li, Xinran, Wang, Jingyu, Gao, Zhongai, Chang, Baocheng, Yang, Juhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551351/ https://www.ncbi.nlm.nih.gov/pubmed/36237185 http://dx.doi.org/10.3389/fendo.2022.960835

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