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Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage
BACKGROUND AND AIMS: Transient Elastography is a non-invasive, cost-efficient, non-ionizing, observer-independent and reliable method to detect liver fibrosis using Liver Stiffness Measurement (LSM) and the degree of fat accumulation in the liver using Controlled Attenuation Parameter (CAP). This st...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551398/ https://www.ncbi.nlm.nih.gov/pubmed/36237190 http://dx.doi.org/10.3389/fendo.2022.1030809 |
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author | Brunnert, Lina Puasa, Ika Damayanti Garten, Antje Penke, Melanie Gaul, Susanne Grafe, Nico Karlas, Thomas Kiess, Wieland Flemming, Gunter Vogel, Mandy |
author_facet | Brunnert, Lina Puasa, Ika Damayanti Garten, Antje Penke, Melanie Gaul, Susanne Grafe, Nico Karlas, Thomas Kiess, Wieland Flemming, Gunter Vogel, Mandy |
author_sort | Brunnert, Lina |
collection | PubMed |
description | BACKGROUND AND AIMS: Transient Elastography is a non-invasive, cost-efficient, non-ionizing, observer-independent and reliable method to detect liver fibrosis using Liver Stiffness Measurement (LSM) and the degree of fat accumulation in the liver using Controlled Attenuation Parameter (CAP). This study aims to derive reference values for both measures from healthy children and adolescents. Further, we aim to assess the potential influence of age, sex, puberty, and BMI-SDS on CAP and LSM. METHODS: Within the LIFE Child study, amongst others, anthropometric data and pubertal status were assessed. Transient Elastography (TE) was performed using the FibroScan(®) device in a population-based cohort at 982 study visits of 482 healthy children aged between 10 and 18 years. Percentiles for LSM and CAP were estimated, and the effects of age, sex, puberty and weight status were assessed through hierarchical regression models. RESULTS: There was a strong age dependency for LSM with higher values for older children, most pronounced in the upper percentiles in boys. Contrarily, CAP was relatively stable across the age span without considerable difference between boys and girls. We found a significant positive correlation between BMI-SDS and both CAP and LSM for BMI-SDS >1.28. For BMI-SDS < 1.28, the association was also positive but reached statistical significance only for CAP. Further, the association between BMI-SDS and CAP was significantly stronger in younger than in older children. There was no association between pubertal status and CAP. For LSM, we found that children with a high BMI-SDS but not children with normal weight had significantly higher LSM values in Tanner stage 4. CONCLUSIONS: Age, sex, pubertal status and weight status should be considered when interpreting LSM and CAP in pediatric patients to facilitate and improve early detection of abnormal liver function, which is associated with common pathologies, such as NAFLD. |
format | Online Article Text |
id | pubmed-9551398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95513982022-10-12 Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage Brunnert, Lina Puasa, Ika Damayanti Garten, Antje Penke, Melanie Gaul, Susanne Grafe, Nico Karlas, Thomas Kiess, Wieland Flemming, Gunter Vogel, Mandy Front Endocrinol (Lausanne) Endocrinology BACKGROUND AND AIMS: Transient Elastography is a non-invasive, cost-efficient, non-ionizing, observer-independent and reliable method to detect liver fibrosis using Liver Stiffness Measurement (LSM) and the degree of fat accumulation in the liver using Controlled Attenuation Parameter (CAP). This study aims to derive reference values for both measures from healthy children and adolescents. Further, we aim to assess the potential influence of age, sex, puberty, and BMI-SDS on CAP and LSM. METHODS: Within the LIFE Child study, amongst others, anthropometric data and pubertal status were assessed. Transient Elastography (TE) was performed using the FibroScan(®) device in a population-based cohort at 982 study visits of 482 healthy children aged between 10 and 18 years. Percentiles for LSM and CAP were estimated, and the effects of age, sex, puberty and weight status were assessed through hierarchical regression models. RESULTS: There was a strong age dependency for LSM with higher values for older children, most pronounced in the upper percentiles in boys. Contrarily, CAP was relatively stable across the age span without considerable difference between boys and girls. We found a significant positive correlation between BMI-SDS and both CAP and LSM for BMI-SDS >1.28. For BMI-SDS < 1.28, the association was also positive but reached statistical significance only for CAP. Further, the association between BMI-SDS and CAP was significantly stronger in younger than in older children. There was no association between pubertal status and CAP. For LSM, we found that children with a high BMI-SDS but not children with normal weight had significantly higher LSM values in Tanner stage 4. CONCLUSIONS: Age, sex, pubertal status and weight status should be considered when interpreting LSM and CAP in pediatric patients to facilitate and improve early detection of abnormal liver function, which is associated with common pathologies, such as NAFLD. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9551398/ /pubmed/36237190 http://dx.doi.org/10.3389/fendo.2022.1030809 Text en Copyright © 2022 Brunnert, Puasa, Garten, Penke, Gaul, Grafe, Karlas, Kiess, Flemming and Vogel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Brunnert, Lina Puasa, Ika Damayanti Garten, Antje Penke, Melanie Gaul, Susanne Grafe, Nico Karlas, Thomas Kiess, Wieland Flemming, Gunter Vogel, Mandy Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
title | Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
title_full | Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
title_fullStr | Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
title_full_unstemmed | Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
title_short | Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
title_sort | pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551398/ https://www.ncbi.nlm.nih.gov/pubmed/36237190 http://dx.doi.org/10.3389/fendo.2022.1030809 |
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