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Activation of the β-TrCP/IκBα/inflammation axis limits the sensitivity of liver cancer cells to neddylation inhibition

Upregulation of protein neddylation occurs in numerous types of human cancer, including liver cancer. MLN4924, a potent neddylation-inhibiting pharmacological agent, demonstrates anticancer ability in numerous cancers. However, the sensitivity of MLN4924 in liver cancer remains unsatisfactory due to...

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Detalles Bibliográficos
Autores principales:	Xiong, Haojun, Zheng, Dandan, Liu, Ying, Ma, Lihai, Meng, Lingzhan, Yang, Zhenzhou, Yang, Zhixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551660/ https://www.ncbi.nlm.nih.gov/pubmed/36169173 http://dx.doi.org/10.3892/or.2022.8416

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