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Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications

BACKGROUND: Although platelet indices are routinely available using automated blood cell counters, the clinical applications of these parameters for malaria and dengue hemorrhagic fever (DHF) have not been substantially implemented. We conducted this study to investigate the potential role of platel...

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Autores principales: Mon, Nant The Su, Tangpukdee, Noppadon, Charunwatthana, Prakaykaew, Boonnak, Kobporn, Krudsood, Srivicha, Kano, Shigeyuki, Wilairatana, Polrat, Leowattana, Wattana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552151/
https://www.ncbi.nlm.nih.gov/pubmed/36221147
http://dx.doi.org/10.1186/s41182-022-00467-8
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author Mon, Nant The Su
Tangpukdee, Noppadon
Charunwatthana, Prakaykaew
Boonnak, Kobporn
Krudsood, Srivicha
Kano, Shigeyuki
Wilairatana, Polrat
Leowattana, Wattana
author_facet Mon, Nant The Su
Tangpukdee, Noppadon
Charunwatthana, Prakaykaew
Boonnak, Kobporn
Krudsood, Srivicha
Kano, Shigeyuki
Wilairatana, Polrat
Leowattana, Wattana
author_sort Mon, Nant The Su
collection PubMed
description BACKGROUND: Although platelet indices are routinely available using automated blood cell counters, the clinical applications of these parameters for malaria and dengue hemorrhagic fever (DHF) have not been substantially implemented. We conducted this study to investigate the potential role of platelet indices as a prognostic marker in adult patients with Plasmodium vivax malaria, Plasmodium falciparum malaria, and DHF admitted to the Hospital for Tropical Diseases, Bangkok, Thailand. METHODS: We enrolled 219 eligible patients, comprising 96 with P. falciparum malaria, 71 with P. vivax malaria, and 52 with DHF. We evaluated the study groups’ baseline clinical features and alterations of platelet indices during the first 4 days of admission. RESULTS: Upon admission, the initial laboratory findings showed no statistically significant difference in platelet count (PC), plateletcrit (PCT), or platelet distribution width (PDW) between patients with P. vivax and P. falciparum; however, mean platelet volume (MPV) was significantly higher in patients with P. falciparum. Comparisons of the initial platelet indices in malaria and DHF showed that only PC and PCT were significantly lower in DHF. Although MPV in DHF tended to be lower than in malaria, a statistically significant difference was observed only with P. falciparum. Moreover, the results also showed no significant alterations in the platelet indices among the study groups during the first 4 days of admission. CONCLUSIONS AND RECOMMENDATIONS: Clinical presentations of DHF and malaria are nonspecific and may overlap with other common tropical diseases. Alterations of initial platelet indices may be investigated in P. vivax and P. falciparum malaria mimicking DHF. Although a significant reduction in PC and PCT in DHF might be a clue for differential diagnosis of malaria, the use of MPV and PDW might be impractical. We suggest that appropriate laboratory diagnoses for malaria and dengue infections are still needed for the differential diagnosis of acute febrile patients who have a risk of malaria or dengue infections. To clarify the clinical utility of platelet indices in patients with dengue and malaria, further studies are required that particularly include patients with different severities, geographical areas, and levels of health care settings.
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spelling pubmed-95521512022-10-11 Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications Mon, Nant The Su Tangpukdee, Noppadon Charunwatthana, Prakaykaew Boonnak, Kobporn Krudsood, Srivicha Kano, Shigeyuki Wilairatana, Polrat Leowattana, Wattana Trop Med Health Research BACKGROUND: Although platelet indices are routinely available using automated blood cell counters, the clinical applications of these parameters for malaria and dengue hemorrhagic fever (DHF) have not been substantially implemented. We conducted this study to investigate the potential role of platelet indices as a prognostic marker in adult patients with Plasmodium vivax malaria, Plasmodium falciparum malaria, and DHF admitted to the Hospital for Tropical Diseases, Bangkok, Thailand. METHODS: We enrolled 219 eligible patients, comprising 96 with P. falciparum malaria, 71 with P. vivax malaria, and 52 with DHF. We evaluated the study groups’ baseline clinical features and alterations of platelet indices during the first 4 days of admission. RESULTS: Upon admission, the initial laboratory findings showed no statistically significant difference in platelet count (PC), plateletcrit (PCT), or platelet distribution width (PDW) between patients with P. vivax and P. falciparum; however, mean platelet volume (MPV) was significantly higher in patients with P. falciparum. Comparisons of the initial platelet indices in malaria and DHF showed that only PC and PCT were significantly lower in DHF. Although MPV in DHF tended to be lower than in malaria, a statistically significant difference was observed only with P. falciparum. Moreover, the results also showed no significant alterations in the platelet indices among the study groups during the first 4 days of admission. CONCLUSIONS AND RECOMMENDATIONS: Clinical presentations of DHF and malaria are nonspecific and may overlap with other common tropical diseases. Alterations of initial platelet indices may be investigated in P. vivax and P. falciparum malaria mimicking DHF. Although a significant reduction in PC and PCT in DHF might be a clue for differential diagnosis of malaria, the use of MPV and PDW might be impractical. We suggest that appropriate laboratory diagnoses for malaria and dengue infections are still needed for the differential diagnosis of acute febrile patients who have a risk of malaria or dengue infections. To clarify the clinical utility of platelet indices in patients with dengue and malaria, further studies are required that particularly include patients with different severities, geographical areas, and levels of health care settings. BioMed Central 2022-10-11 /pmc/articles/PMC9552151/ /pubmed/36221147 http://dx.doi.org/10.1186/s41182-022-00467-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Mon, Nant The Su
Tangpukdee, Noppadon
Charunwatthana, Prakaykaew
Boonnak, Kobporn
Krudsood, Srivicha
Kano, Shigeyuki
Wilairatana, Polrat
Leowattana, Wattana
Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
title Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
title_full Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
title_fullStr Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
title_full_unstemmed Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
title_short Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
title_sort mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552151/
https://www.ncbi.nlm.nih.gov/pubmed/36221147
http://dx.doi.org/10.1186/s41182-022-00467-8
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