Mutations Increasing Cofactor Affinity, Improve Stability and Activity of a Baeyer–Villiger Monooxygenase

[Image: see text] The typically low thermodynamic and kinetic stability of enzymes is a bottleneck for their application in industrial synthesis. Baeyer–Villiger monooxygenases, which oxidize ketones to lactones using aerial oxygen, among other activities, suffer particularly from these instabilitie...

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Detalles Bibliográficos
Autores principales: Mansouri, Hamid R., Gracia Carmona, Oriol, Jodlbauer, Julia, Schweiger, Lorenz, Fink, Michael J., Breslmayr, Erik, Laurent, Christophe, Feroz, Saima, P. Goncalves, Leticia C., Rial, Daniela V., Mihovilovic, Marko D., Bommarius, Andreas S., Ludwig, Roland, Oostenbrink, Chris, Rudroff, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552169/
https://www.ncbi.nlm.nih.gov/pubmed/36249873
http://dx.doi.org/10.1021/acscatal.2c03225

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