An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals

To evaluate the immunotoxic effects of xenobiotics, we have established the Multi-ImmunoTox assay, in which three stable reporter cell lines are used to evaluate the effects of chemicals on the IL-2, IFN-γ, IL-1β and IL-8 promoters. Here, we report the official validation study of the IL-2 luciferas...

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Detalles Bibliográficos
Autores principales: Kimura, Yutaka, Yasuno, Rie, Watanabe, Mika, Kobayashi, Miwako, Iwaki, Tomoko, Fujimura, Chizu, Ohmiya, Yoshihiro, Yamakage, Kohji, Nakajima, Yoshihiro, Kobayashi, Mayumi, Mashimo, Nana, Takagi, Yumi, Omori, Takashi, Corsini, Emanuela, Germolec, Dori, Inoue, Tomoaki, Rogen, Erwin L., Kojima, Hajime, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552337/
https://www.ncbi.nlm.nih.gov/pubmed/32200032
http://dx.doi.org/10.1016/j.tiv.2020.104832

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