Cargando…
Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study
BACKGROUND & OBJECTIVES: Serology testing is essential for immunological surveillance in the population. This serosurvey was conducted to ascertain the cumulative population immunity against SARS-CoV-2 among adults in Jammu district and to understand the association of seropositivity with sociod...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552381/ https://www.ncbi.nlm.nih.gov/pubmed/35859442 http://dx.doi.org/10.4103/ijmr.IJMR_4489_20 |
_version_ | 1784806238171693056 |
---|---|
author | Kumar, Dinesh Sidhu, Meena Dogra, Sandeep Kumar, Bhupinder Sahni, Bhavna Yadav, Arvind Kumar Bala, Kiran Kumari, Rashmi Mahajan, Richa Bavoria, Shalli Kalotra, Anuradha Gupta, Sachin |
author_facet | Kumar, Dinesh Sidhu, Meena Dogra, Sandeep Kumar, Bhupinder Sahni, Bhavna Yadav, Arvind Kumar Bala, Kiran Kumari, Rashmi Mahajan, Richa Bavoria, Shalli Kalotra, Anuradha Gupta, Sachin |
author_sort | Kumar, Dinesh |
collection | PubMed |
description | BACKGROUND & OBJECTIVES: Serology testing is essential for immunological surveillance in the population. This serosurvey was conducted to ascertain the cumulative population immunity against SARS-CoV-2 among adults in Jammu district and to understand the association of seropositivity with sociodemographic and clinical correlates. METHODS: On September 30 and October 1, 2020, a household survey was done in 20 villages/wards chosen from 10 health blocks in district Jammu, India. Demographic, clinical and exposure information was collected from 2000 adults. Serum samples were screened for IgG antibodies using COVID Kavach MERILISA kit. Tests of association were used to identify risk factors associated with IgG positivity. Crude odds ratio with 95 per cent confidence intervals (CIs) was calculated during univariate analysis followed by logistic regression. RESULTS: Overall adjusted seroprevalence for SARS-CoV-2 was 8.8 per cent (95% CI: 8.78-8.82); it varied from 4.1 per cent in Chauki choura to 16.7 per cent Pallanwalla across 10 blocks in the district. Seropositivity was observed to be comparatively higher in 41-50 and 61-70 yr age groups, among males and in rural areas. Fever, sore throat, cough, dyspnoea, myalgias, anosmia, ageusia, fatigue, seizures, history of exposure, medical consultation, hospitalization and missing work showed significant association with seropositivity on univariate analysis. On logistic regression, only sore throat, myalgia and missing work showed significant adjusted odds of IgG positivity. Extrapolation to adult population suggested that exposure to SARS-CoV-2 was 14.4 times higher than reported cases, translating into Infection fatality rate of 0.08 per cent. INTERPRETATION & CONCLUSIONS: Since a major part of population was immunologically naive, all efforts to contain COVID-19 need to be vigorously followed while these baseline results provide an important yardstick to monitor the trends of COVID-19 and guide locally appropriate control strategies in the region. |
format | Online Article Text |
id | pubmed-9552381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-95523812022-10-12 Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study Kumar, Dinesh Sidhu, Meena Dogra, Sandeep Kumar, Bhupinder Sahni, Bhavna Yadav, Arvind Kumar Bala, Kiran Kumari, Rashmi Mahajan, Richa Bavoria, Shalli Kalotra, Anuradha Gupta, Sachin Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Serology testing is essential for immunological surveillance in the population. This serosurvey was conducted to ascertain the cumulative population immunity against SARS-CoV-2 among adults in Jammu district and to understand the association of seropositivity with sociodemographic and clinical correlates. METHODS: On September 30 and October 1, 2020, a household survey was done in 20 villages/wards chosen from 10 health blocks in district Jammu, India. Demographic, clinical and exposure information was collected from 2000 adults. Serum samples were screened for IgG antibodies using COVID Kavach MERILISA kit. Tests of association were used to identify risk factors associated with IgG positivity. Crude odds ratio with 95 per cent confidence intervals (CIs) was calculated during univariate analysis followed by logistic regression. RESULTS: Overall adjusted seroprevalence for SARS-CoV-2 was 8.8 per cent (95% CI: 8.78-8.82); it varied from 4.1 per cent in Chauki choura to 16.7 per cent Pallanwalla across 10 blocks in the district. Seropositivity was observed to be comparatively higher in 41-50 and 61-70 yr age groups, among males and in rural areas. Fever, sore throat, cough, dyspnoea, myalgias, anosmia, ageusia, fatigue, seizures, history of exposure, medical consultation, hospitalization and missing work showed significant association with seropositivity on univariate analysis. On logistic regression, only sore throat, myalgia and missing work showed significant adjusted odds of IgG positivity. Extrapolation to adult population suggested that exposure to SARS-CoV-2 was 14.4 times higher than reported cases, translating into Infection fatality rate of 0.08 per cent. INTERPRETATION & CONCLUSIONS: Since a major part of population was immunologically naive, all efforts to contain COVID-19 need to be vigorously followed while these baseline results provide an important yardstick to monitor the trends of COVID-19 and guide locally appropriate control strategies in the region. Wolters Kluwer - Medknow 2022-01 /pmc/articles/PMC9552381/ /pubmed/35859442 http://dx.doi.org/10.4103/ijmr.IJMR_4489_20 Text en Copyright: © 2022 Indian Journal of Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kumar, Dinesh Sidhu, Meena Dogra, Sandeep Kumar, Bhupinder Sahni, Bhavna Yadav, Arvind Kumar Bala, Kiran Kumari, Rashmi Mahajan, Richa Bavoria, Shalli Kalotra, Anuradha Gupta, Sachin Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study |
title | Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study |
title_full | Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study |
title_fullStr | Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study |
title_full_unstemmed | Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study |
title_short | Seroprevalence of anti SARS-CoV-2 IgG antibodies among adults in Jammu district, India: A community-based study |
title_sort | seroprevalence of anti sars-cov-2 igg antibodies among adults in jammu district, india: a community-based study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552381/ https://www.ncbi.nlm.nih.gov/pubmed/35859442 http://dx.doi.org/10.4103/ijmr.IJMR_4489_20 |
work_keys_str_mv | AT kumardinesh seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT sidhumeena seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT dograsandeep seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT kumarbhupinder seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT sahnibhavna seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT yadavarvindkumar seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT balakiran seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT kumarirashmi seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT mahajanricha seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT bavoriashalli seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT kalotraanuradha seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy AT guptasachin seroprevalenceofantisarscov2iggantibodiesamongadultsinjammudistrictindiaacommunitybasedstudy |