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Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice
PPARγ agonists have been proven to be neuroprotective in vitro and in vivo models of Alzheimer’s disease (AD). In the present study, we identified ligustrazine piperazine derivative (LPD) as a novel PPARγ agonist, which was detected by a dual-luciferase reporter assay system. LPD treatment dose-depe...
Autores principales: | Li, Zongyang, Meng, Xiangbao, Ma, Guoxu, Liu, Wenlan, Li, Weiping, Cai, Qian, Wang, Sicen, Huang, Guodong, Zhang, Yuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552451/ https://www.ncbi.nlm.nih.gov/pubmed/36217155 http://dx.doi.org/10.1186/s13195-022-01092-7 |
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