Cargando…

Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice

PPARγ agonists have been proven to be neuroprotective in vitro and in vivo models of Alzheimer’s disease (AD). In the present study, we identified ligustrazine piperazine derivative (LPD) as a novel PPARγ agonist, which was detected by a dual-luciferase reporter assay system. LPD treatment dose-depe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zongyang, Meng, Xiangbao, Ma, Guoxu, Liu, Wenlan, Li, Weiping, Cai, Qian, Wang, Sicen, Huang, Guodong, Zhang, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552451/ https://www.ncbi.nlm.nih.gov/pubmed/36217155 http://dx.doi.org/10.1186/s13195-022-01092-7

Ejemplares similares

Intranasal 15d-PGJ2 inhibits the growth of rat lactotroph pituitary neuroendocrine tumors by inducing PPARγ-dependent apoptotic and autophagic cell death
por: Li, Zongyang, et al.
Publicado: (2023)

A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation
por: Xie, Cong, et al.
Publicado: (2022)

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis
por: Xue, Xiang, et al.
Publicado: (2023)

Abscisic acid interplays with PPARγ receptors and ameliorates diabetes-induced cognitive deficits in rats
por: Kooshki, Razieh, et al.
Publicado: (2021)

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
por: Yang, Wenjuan, et al.
Publicado: (2018)

Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α
por: Zhang, Feng, et al.
Publicado: (2018)

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits
por: Kummer, Markus P., et al.
Publicado: (2014)

Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α: Erratum
por: Zhang, Feng, et al.
Publicado: (2022)

FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment
por: Sun, Xingzong, et al.
Publicado: (2023)

Ligustrazine ameliorates acute kidney injury through downregulation of NOD2-mediated inflammation
por: Jiang, Guosheng, et al.
Publicado: (2020)

Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy
por: Zhou, Ping, et al.
Publicado: (2019)

Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits
por: Cortez, Ibdanelo, et al.
Publicado: (2019)

Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice
por: Shi, Jing, et al.
Publicado: (2023)

Alterations of the Gut Microbiome in Patients With Pituitary Adenoma
por: Hu, Jinxian, et al.
Publicado: (2022)

Electroacupuncture ameliorates surgery-induced spatial memory deficits by promoting mitophagy in rats
por: Guo, Jian, et al.
Publicado: (2023)

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats
por: Liu, Dandan, et al.
Publicado: (2023)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
por: Wang, Xu, et al.
Publicado: (2017)

Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice
por: Wang, Zigao, et al.
Publicado: (2017)

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis
por: Lin, Kaili, et al.
Publicado: (2021)

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss
por: Zhou, Wei, et al.
Publicado: (2019)

Promoted CD4(+) T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice
por: Wu, Xiaolei, et al.
Publicado: (2022)

Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ
por: Liu, Jinhong, et al.
Publicado: (2020)

Targeting mitophagy for depression amelioration: a novel therapeutic strategy
por: Xu, Wangjun, et al.
Publicado: (2023)

Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
por: Yang, Yunjie, et al.
Publicado: (2020)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Ligustrazine monomer against cerebral ischemia/reperfusion injury
por: Gao, Hai-jun, et al.
Publicado: (2015)

Effect of Ligustrazine on Endometrium Injury of Thin Endometrium Rats
por: Ye, Qing, et al.
Publicado: (2019)

Ligustrazine inhibits the viability and motility of colon cancer cells
por: Chen, Xiaochao, et al.
Publicado: (2020)

Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents
por: Ma, Shitang, et al.
Publicado: (2022)

Ligustrazine Inhibits the Migration and Invasion of Renal Cell Carcinoma
por: Zhang, Xufeng, et al.
Publicado: (2023)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

PPARγ Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
por: Han, Jee-Young, et al.
Publicado: (2010)

Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice
por: Jiang, Rong, et al.
Publicado: (2020)

Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver
por: El-Sheikh, Azza A. K., et al.
Publicado: (2014)

Ligustrazine ameliorates lipopolysaccharide-induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway
por: Li, Guangming, et al.
Publicado: (2020)

Long-term icariin treatment ameliorates cognitive deficits via CD4(+) T cell-mediated immuno-inflammatory responses in APP/PS1 mice
por: Zhu, Tianrui, et al.
Publicado: (2019)

Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice
por: Su, Qiang, et al.
Publicado: (2021)

Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction
por: Yu, Tian, et al.
Publicado: (2016)

Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation
por: Park, Chung-Hwa, et al.
Publicado: (2017)

PPARγ and Apoptosis in Cancer
por: Elrod, Heath A., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_h1ka2tq3tivg8oa4en76nj95sv