Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia

BACKGROUND: Chronic neuroinflammation is one of the hallmarks of late-onset Alzheimer’s disease (AD) dementia pathogenesis. Carrying the apolipoprotein ε4 (APOE4) allele has been associated with an accentuated response to brain inflammation and increases the risk of AD dementia progression. Among in...

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Detalles Bibliográficos
Autores principales: Ebright, Brandon, Assante, Isaac, Poblete, Roy A., Wang, Shaowei, Duro, Marlon V., Bennett, David A., Arvanitakis, Zoe, Louie, Stan G., Yassine, Hussein N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552454/
https://www.ncbi.nlm.nih.gov/pubmed/36217192
http://dx.doi.org/10.1186/s13195-022-01084-7

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