Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

BACKGROUND: Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polygenic risk score (PRS) analysis to illustrate the new genetic architectures of go...

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Detalles Bibliográficos
Autores principales: Chang, Ya-Sian, Lin, Chien-Yu, Liu, Ting-Yuan, Huang, Chung-Ming, Chung, Chin-Chun, Chen, Yu-Chia, Tsai, Fuu-Jen, Chang, Jan-Gowth, Chang, Shun-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552457/
https://www.ncbi.nlm.nih.gov/pubmed/36221101
http://dx.doi.org/10.1186/s13075-022-02917-4

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