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Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis
BACKGROUND: As a natural antioxidant, uric acid plays a protective role against neurodegenerative disorders, including Parkinson’s disease (PD). Therefore, the risk of PD has been found to be lower in people with hyperuricemia. In this article, we conducted a systematic review and meta-analysis to i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552480/ https://www.ncbi.nlm.nih.gov/pubmed/36221048 http://dx.doi.org/10.1186/s12883-022-02874-0 |
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author | Fazlollahi, Asra Zahmatyar, Mahdi Alizadeh, Hossein Noori, Maryam Jafari, Nasrin Nejadghaderi, Seyed Aria Sullman, Mark J. M. Gharagozli, Koroush Kolahi, Ali-Asghar Safiri, Saeid |
author_facet | Fazlollahi, Asra Zahmatyar, Mahdi Alizadeh, Hossein Noori, Maryam Jafari, Nasrin Nejadghaderi, Seyed Aria Sullman, Mark J. M. Gharagozli, Koroush Kolahi, Ali-Asghar Safiri, Saeid |
author_sort | Fazlollahi, Asra |
collection | PubMed |
description | BACKGROUND: As a natural antioxidant, uric acid plays a protective role against neurodegenerative disorders, including Parkinson’s disease (PD). Therefore, the risk of PD has been found to be lower in people with hyperuricemia. In this article, we conducted a systematic review and meta-analysis to investigate whether gout affects the future risk of developing PD. METHODS: We searched PubMed, Scopus, the Web of Science, and Google Scholar to find relevant studies, up to March 16, 2022. Studies investigating the risk of PD, following a gout diagnosis, were included if they were cross-sectional, case–control or cohort studies. The Newcastle Ottawa Scale (NOS) checklist was used to assess the quality of all included studies. The meta-analysis was performed using STATA 17.0. RESULTS: Ten studies were included, which were comprised of three case-controls, six cohort studies and one nested case–control study. We found no significant association between gout and the risk of PD among both sexes (RR = 0.94, 95% CI: 0.86–1.04), although the association was significant for females (RR = 1.09; 95% CI: 1.02–1.17). Subgroup analysis also showed no significant findings by age group, whether they were receiving treatment for gout, study design, quality assessment score, and method of gout ascertainment. In contrast, the studies that defined PD according to the use of drugs showed significant results (RR = 0.82; 95% CI: 0.76–0.89). There was a significant publication bias on the association between gout and PD. CONCLUSIONS: The presence of gout had no significant effect on the risk of subsequently developing PD. Further analyses are recommended to investigate the effects of demographic and behavioral risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-02874-0. |
format | Online Article Text |
id | pubmed-9552480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95524802022-10-12 Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis Fazlollahi, Asra Zahmatyar, Mahdi Alizadeh, Hossein Noori, Maryam Jafari, Nasrin Nejadghaderi, Seyed Aria Sullman, Mark J. M. Gharagozli, Koroush Kolahi, Ali-Asghar Safiri, Saeid BMC Neurol Research BACKGROUND: As a natural antioxidant, uric acid plays a protective role against neurodegenerative disorders, including Parkinson’s disease (PD). Therefore, the risk of PD has been found to be lower in people with hyperuricemia. In this article, we conducted a systematic review and meta-analysis to investigate whether gout affects the future risk of developing PD. METHODS: We searched PubMed, Scopus, the Web of Science, and Google Scholar to find relevant studies, up to March 16, 2022. Studies investigating the risk of PD, following a gout diagnosis, were included if they were cross-sectional, case–control or cohort studies. The Newcastle Ottawa Scale (NOS) checklist was used to assess the quality of all included studies. The meta-analysis was performed using STATA 17.0. RESULTS: Ten studies were included, which were comprised of three case-controls, six cohort studies and one nested case–control study. We found no significant association between gout and the risk of PD among both sexes (RR = 0.94, 95% CI: 0.86–1.04), although the association was significant for females (RR = 1.09; 95% CI: 1.02–1.17). Subgroup analysis also showed no significant findings by age group, whether they were receiving treatment for gout, study design, quality assessment score, and method of gout ascertainment. In contrast, the studies that defined PD according to the use of drugs showed significant results (RR = 0.82; 95% CI: 0.76–0.89). There was a significant publication bias on the association between gout and PD. CONCLUSIONS: The presence of gout had no significant effect on the risk of subsequently developing PD. Further analyses are recommended to investigate the effects of demographic and behavioral risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-02874-0. BioMed Central 2022-10-11 /pmc/articles/PMC9552480/ /pubmed/36221048 http://dx.doi.org/10.1186/s12883-022-02874-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Fazlollahi, Asra Zahmatyar, Mahdi Alizadeh, Hossein Noori, Maryam Jafari, Nasrin Nejadghaderi, Seyed Aria Sullman, Mark J. M. Gharagozli, Koroush Kolahi, Ali-Asghar Safiri, Saeid Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis |
title | Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis |
title_full | Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis |
title_fullStr | Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis |
title_full_unstemmed | Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis |
title_short | Association between gout and the development of Parkinson’s disease: a systematic review and meta-analysis |
title_sort | association between gout and the development of parkinson’s disease: a systematic review and meta-analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552480/ https://www.ncbi.nlm.nih.gov/pubmed/36221048 http://dx.doi.org/10.1186/s12883-022-02874-0 |
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