Cargando…

Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases

We present a clinical case where a complex abnormal non‐invasive prenatal test (NIPT) result in a research project revealed carcinoma of the breast in the pregnant woman. Furthermore, the NIPT result did not demonstrate the same fetal chromosomal aberration as the chorion villus sample. A literature...

Descripción completa

Detalles Bibliográficos
Autores principales: Moellgaard, Maria Hammer, Lund, Ida Charlotte Bay, Becher, Naja, Skytte, Anne‐Bine, Andreasen, Lotte, Srebniak, Malgorzata Ilona, Vogel, Ida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552546/
https://www.ncbi.nlm.nih.gov/pubmed/36245448
http://dx.doi.org/10.1002/ccr3.6280
_version_ 1784806272871170048
author Moellgaard, Maria Hammer
Lund, Ida Charlotte Bay
Becher, Naja
Skytte, Anne‐Bine
Andreasen, Lotte
Srebniak, Malgorzata Ilona
Vogel, Ida
author_facet Moellgaard, Maria Hammer
Lund, Ida Charlotte Bay
Becher, Naja
Skytte, Anne‐Bine
Andreasen, Lotte
Srebniak, Malgorzata Ilona
Vogel, Ida
author_sort Moellgaard, Maria Hammer
collection PubMed
description We present a clinical case where a complex abnormal non‐invasive prenatal test (NIPT) result in a research project revealed carcinoma of the breast in the pregnant woman. Furthermore, the NIPT result did not demonstrate the same fetal chromosomal aberration as the chorion villus sample. A literature search for similar cases was performed identifying 43 unique cases, where abnormal NIPT results were related to maternal malignancy. Malignancy is a rare but important cause of complex abnormal non‐invasive prenatal test (NIPT) results and should be considered when fetal karyotype and abnormal NIPT results are discordant. Furthermore, a follow‐up invasive sample is essential for correct fetal diagnosis when abnormal NIPT results are found.
format Online
Article
Text
id pubmed-9552546
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-95525462022-10-14 Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases Moellgaard, Maria Hammer Lund, Ida Charlotte Bay Becher, Naja Skytte, Anne‐Bine Andreasen, Lotte Srebniak, Malgorzata Ilona Vogel, Ida Clin Case Rep Case Report We present a clinical case where a complex abnormal non‐invasive prenatal test (NIPT) result in a research project revealed carcinoma of the breast in the pregnant woman. Furthermore, the NIPT result did not demonstrate the same fetal chromosomal aberration as the chorion villus sample. A literature search for similar cases was performed identifying 43 unique cases, where abnormal NIPT results were related to maternal malignancy. Malignancy is a rare but important cause of complex abnormal non‐invasive prenatal test (NIPT) results and should be considered when fetal karyotype and abnormal NIPT results are discordant. Furthermore, a follow‐up invasive sample is essential for correct fetal diagnosis when abnormal NIPT results are found. John Wiley and Sons Inc. 2022-10-11 /pmc/articles/PMC9552546/ /pubmed/36245448 http://dx.doi.org/10.1002/ccr3.6280 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Moellgaard, Maria Hammer
Lund, Ida Charlotte Bay
Becher, Naja
Skytte, Anne‐Bine
Andreasen, Lotte
Srebniak, Malgorzata Ilona
Vogel, Ida
Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
title Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
title_full Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
title_fullStr Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
title_full_unstemmed Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
title_short Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
title_sort incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552546/
https://www.ncbi.nlm.nih.gov/pubmed/36245448
http://dx.doi.org/10.1002/ccr3.6280
work_keys_str_mv AT moellgaardmariahammer incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases
AT lundidacharlottebay incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases
AT bechernaja incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases
AT skytteannebine incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases
AT andreasenlotte incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases
AT srebniakmalgorzatailona incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases
AT vogelida incidentalfindingofmaternalmalignancyinanunusualnoninvasiveprenataltestandareviewofsimilarcases