Wolf’s Isotopic Response After Herpes Zoster Infection in Chronic Lichen Sclerosus-Like Graft versus Host Disease: Case Report and Literature Review

Wolf’s isotopic response (WIR) refers to the occurrence of a new skin disease at the exact site of an unrelated skin disease that had previously healed, often subsequent to virus infection. Secondary cutaneous diseases that are frequently observed in WIR include granulomatous reactions, dysimmune reactions, malignancies, and infections. However, secondary chronic graft-versus-host disease (GVHD) is rare. We describe a patient with lichen sclerosus-like GVHD who developed lichen planus-like GVHD lesions secondary to herpes zoster infection.