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Neural computations underlying contextual processing in humans

Context shapes our perception of facial expressions during everyday social interactions. We interpret a person’s face in a hostile situation negatively and judge the same face under pleasant circumstances positively. Critical to our adaptive fitness, context provides situation-specific framing to re...

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Detalles Bibliográficos
Autores principales: Zheng, Jie, Skelin, Ivan, Lin, Jack J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552771/
https://www.ncbi.nlm.nih.gov/pubmed/36130515
http://dx.doi.org/10.1016/j.celrep.2022.111395
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author Zheng, Jie
Skelin, Ivan
Lin, Jack J.
author_facet Zheng, Jie
Skelin, Ivan
Lin, Jack J.
author_sort Zheng, Jie
collection PubMed
description Context shapes our perception of facial expressions during everyday social interactions. We interpret a person’s face in a hostile situation negatively and judge the same face under pleasant circumstances positively. Critical to our adaptive fitness, context provides situation-specific framing to resolve ambiguity and guide our interpersonal behavior. This context-specific modulation of facial expression is thought to engage the amygdala, hippocampus, and orbitofrontal cortex; however, the underlying neural computations remain unknown. Here we use human intracranial electroencephalograms (EEGs) directly recorded from these regions and report bidirectional theta-gamma interactions within the amygdala-hippocampal network, facilitating contextual processing. Contextual information is subsequently represented in the orbitofrontal cortex, where a theta phase shift binds context and face associations within theta cycles, endowing faces with contextual meanings at behavioral timescales. Our results identify theta phase shifts as mediating associations between context and face processing, supporting flexible social behavior.
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spelling pubmed-95527712022-10-11 Neural computations underlying contextual processing in humans Zheng, Jie Skelin, Ivan Lin, Jack J. Cell Rep Article Context shapes our perception of facial expressions during everyday social interactions. We interpret a person’s face in a hostile situation negatively and judge the same face under pleasant circumstances positively. Critical to our adaptive fitness, context provides situation-specific framing to resolve ambiguity and guide our interpersonal behavior. This context-specific modulation of facial expression is thought to engage the amygdala, hippocampus, and orbitofrontal cortex; however, the underlying neural computations remain unknown. Here we use human intracranial electroencephalograms (EEGs) directly recorded from these regions and report bidirectional theta-gamma interactions within the amygdala-hippocampal network, facilitating contextual processing. Contextual information is subsequently represented in the orbitofrontal cortex, where a theta phase shift binds context and face associations within theta cycles, endowing faces with contextual meanings at behavioral timescales. Our results identify theta phase shifts as mediating associations between context and face processing, supporting flexible social behavior. 2022-09-20 /pmc/articles/PMC9552771/ /pubmed/36130515 http://dx.doi.org/10.1016/j.celrep.2022.111395 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Zheng, Jie
Skelin, Ivan
Lin, Jack J.
Neural computations underlying contextual processing in humans
title Neural computations underlying contextual processing in humans
title_full Neural computations underlying contextual processing in humans
title_fullStr Neural computations underlying contextual processing in humans
title_full_unstemmed Neural computations underlying contextual processing in humans
title_short Neural computations underlying contextual processing in humans
title_sort neural computations underlying contextual processing in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552771/
https://www.ncbi.nlm.nih.gov/pubmed/36130515
http://dx.doi.org/10.1016/j.celrep.2022.111395
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