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The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker

Modeling how patterns of light and dark affect circadian phase is important clinically and organizationally (e.g., the military) because circadian disruption can compromise health and performance. Limit-cycle oscillator models in various forms have been used to characterize phase changes to a limite...

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Autores principales: Rea, Mark S., Nagare, Rohan, Bierman, Andrew, Figueiro, Mariana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552883/
https://www.ncbi.nlm.nih.gov/pubmed/36238087
http://dx.doi.org/10.3389/fnins.2022.965525
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author Rea, Mark S.
Nagare, Rohan
Bierman, Andrew
Figueiro, Mariana G.
author_facet Rea, Mark S.
Nagare, Rohan
Bierman, Andrew
Figueiro, Mariana G.
author_sort Rea, Mark S.
collection PubMed
description Modeling how patterns of light and dark affect circadian phase is important clinically and organizationally (e.g., the military) because circadian disruption can compromise health and performance. Limit-cycle oscillator models in various forms have been used to characterize phase changes to a limited set of light interventions. We approached the analysis of the van der Pol oscillator-based model proposed by Kronauer and colleagues in 1999 and 2000 (Kronauer99) using a well-established framework from experimental psychology whereby the stimulus (S) acts on the organism (O) to produce a response (R). Within that framework, using four independent data sets utilizing calibrated personal light measurements, we conducted a serial analysis of the factors in the Kronauer99 model that could affect prediction accuracy characterized by changes in dim-light melatonin onset. Prediction uncertainty was slightly greater than 1 h for the new data sets using the original Kronauer99 model. The revised model described here reduced prediction uncertainty for these same data sets by roughly half.
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spelling pubmed-95528832022-10-12 The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker Rea, Mark S. Nagare, Rohan Bierman, Andrew Figueiro, Mariana G. Front Neurosci Neuroscience Modeling how patterns of light and dark affect circadian phase is important clinically and organizationally (e.g., the military) because circadian disruption can compromise health and performance. Limit-cycle oscillator models in various forms have been used to characterize phase changes to a limited set of light interventions. We approached the analysis of the van der Pol oscillator-based model proposed by Kronauer and colleagues in 1999 and 2000 (Kronauer99) using a well-established framework from experimental psychology whereby the stimulus (S) acts on the organism (O) to produce a response (R). Within that framework, using four independent data sets utilizing calibrated personal light measurements, we conducted a serial analysis of the factors in the Kronauer99 model that could affect prediction accuracy characterized by changes in dim-light melatonin onset. Prediction uncertainty was slightly greater than 1 h for the new data sets using the original Kronauer99 model. The revised model described here reduced prediction uncertainty for these same data sets by roughly half. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9552883/ /pubmed/36238087 http://dx.doi.org/10.3389/fnins.2022.965525 Text en Copyright © 2022 Rea, Nagare, Bierman and Figueiro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rea, Mark S.
Nagare, Rohan
Bierman, Andrew
Figueiro, Mariana G.
The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker
title The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker
title_full The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker
title_fullStr The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker
title_full_unstemmed The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker
title_short The circadian stimulus-oscillator model: Improvements to Kronauer’s model of the human circadian pacemaker
title_sort circadian stimulus-oscillator model: improvements to kronauer’s model of the human circadian pacemaker
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552883/
https://www.ncbi.nlm.nih.gov/pubmed/36238087
http://dx.doi.org/10.3389/fnins.2022.965525
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