Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells

Activation of the integrin phagocytic receptors CR3 (α(M)β(2), CD11b/CD18) and CR4 (α(X)β(2), CD11c/CD18) requires Rap1 activation and RIAM function. RIAM controls integrin activation by recruiting Talin to β(2) subunits, enabling the Talin-Vinculin interaction, which in term bridges integrins to th...

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Detalles Bibliográficos
Autores principales: Torres-Gomez, Alvaro, Fiyouzi, Tara, Guerra-Espinosa, Claudia, Cardeñes, Beatriz, Clares, Irene, Toribio, Víctor, Reche, Pedro A., Cabañas, Carlos, Lafuente, Esther M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552961/
https://www.ncbi.nlm.nih.gov/pubmed/36238292
http://dx.doi.org/10.3389/fimmu.2022.951280

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