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NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain

Peripheral and central sensitizations of the trigeminal nervous system are the main mechanisms to promote the development and maintenance of chronic orofacial pain characterized by allodynia, hyperalgesia, and ectopic pain after trigeminal nerve injury or inflammation. Although the pathomechanisms o...

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Autores principales: Liu, Ya-Jing, Li, Yue-Ling, Fang, Zhong-Han, Liao, Hong-Lin, Zhang, Yan-Yan, Lin, Jiu, Liu, Fei, Shen, Jie-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553029/
https://www.ncbi.nlm.nih.gov/pubmed/36238833
http://dx.doi.org/10.3389/fncel.2022.999509
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author Liu, Ya-Jing
Li, Yue-Ling
Fang, Zhong-Han
Liao, Hong-Lin
Zhang, Yan-Yan
Lin, Jiu
Liu, Fei
Shen, Jie-Fei
author_facet Liu, Ya-Jing
Li, Yue-Ling
Fang, Zhong-Han
Liao, Hong-Lin
Zhang, Yan-Yan
Lin, Jiu
Liu, Fei
Shen, Jie-Fei
author_sort Liu, Ya-Jing
collection PubMed
description Peripheral and central sensitizations of the trigeminal nervous system are the main mechanisms to promote the development and maintenance of chronic orofacial pain characterized by allodynia, hyperalgesia, and ectopic pain after trigeminal nerve injury or inflammation. Although the pathomechanisms of chronic orofacial pain are complex and not well known, sufficient clinical and preclinical evidence supports the contribution of the N-methyl-D-aspartate receptors (NMDARs, a subclass of ionotropic glutamate receptors) to the trigeminal nociceptive signal processing pathway under various pathological conditions. NMDARs not only have been implicated as a potential mediator of pain-related neuroplasticity in the peripheral nervous system (PNS) but also mediate excitatory synaptic transmission and synaptic plasticity in the central nervous system (CNS). In this review, we focus on the pivotal roles and mechanisms of NMDARs in the trigeminal nervous system under orofacial neuropathic and inflammatory pain. In particular, we summarize the types, components, and distribution of NMDARs in the trigeminal nervous system. Besides, we discuss the regulatory roles of neuron-nonneuronal cell/neuron-neuron communication mediated by NMDARs in the peripheral mechanisms of chronic orofacial pain following neuropathic injury and inflammation. Furthermore, we review the functional roles and mechanisms of NMDARs in the ascending and descending circuits under orofacial neuropathic and inflammatory pain conditions, which contribute to the central sensitization. These findings are not only relevant to understanding the underlying mechanisms, but also shed new light on the targeted therapy of chronic orofacial pain.
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spelling pubmed-95530292022-10-12 NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain Liu, Ya-Jing Li, Yue-Ling Fang, Zhong-Han Liao, Hong-Lin Zhang, Yan-Yan Lin, Jiu Liu, Fei Shen, Jie-Fei Front Cell Neurosci Cellular Neuroscience Peripheral and central sensitizations of the trigeminal nervous system are the main mechanisms to promote the development and maintenance of chronic orofacial pain characterized by allodynia, hyperalgesia, and ectopic pain after trigeminal nerve injury or inflammation. Although the pathomechanisms of chronic orofacial pain are complex and not well known, sufficient clinical and preclinical evidence supports the contribution of the N-methyl-D-aspartate receptors (NMDARs, a subclass of ionotropic glutamate receptors) to the trigeminal nociceptive signal processing pathway under various pathological conditions. NMDARs not only have been implicated as a potential mediator of pain-related neuroplasticity in the peripheral nervous system (PNS) but also mediate excitatory synaptic transmission and synaptic plasticity in the central nervous system (CNS). In this review, we focus on the pivotal roles and mechanisms of NMDARs in the trigeminal nervous system under orofacial neuropathic and inflammatory pain. In particular, we summarize the types, components, and distribution of NMDARs in the trigeminal nervous system. Besides, we discuss the regulatory roles of neuron-nonneuronal cell/neuron-neuron communication mediated by NMDARs in the peripheral mechanisms of chronic orofacial pain following neuropathic injury and inflammation. Furthermore, we review the functional roles and mechanisms of NMDARs in the ascending and descending circuits under orofacial neuropathic and inflammatory pain conditions, which contribute to the central sensitization. These findings are not only relevant to understanding the underlying mechanisms, but also shed new light on the targeted therapy of chronic orofacial pain. Frontiers Media S.A. 2022-09-27 /pmc/articles/PMC9553029/ /pubmed/36238833 http://dx.doi.org/10.3389/fncel.2022.999509 Text en Copyright © 2022 Liu, Li, Fang, Liao, Zhang, Lin, Liu and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Liu, Ya-Jing
Li, Yue-Ling
Fang, Zhong-Han
Liao, Hong-Lin
Zhang, Yan-Yan
Lin, Jiu
Liu, Fei
Shen, Jie-Fei
NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
title NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
title_full NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
title_fullStr NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
title_full_unstemmed NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
title_short NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
title_sort nmdars mediate peripheral and central sensitization contributing to chronic orofacial pain
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553029/
https://www.ncbi.nlm.nih.gov/pubmed/36238833
http://dx.doi.org/10.3389/fncel.2022.999509
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