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Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study
Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm a...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553056/ https://www.ncbi.nlm.nih.gov/pubmed/36219622 http://dx.doi.org/10.1371/journal.pone.0275893 |
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author | Hunter, Kylie E. Webster, Angela C. Clarke, Mike Page, Matthew J. Libesman, Sol Godolphin, Peter J. Aberoumand, Mason Rydzewska, Larysa H. M. Wang, Rui Tan, Aidan C. Li, Wentao Mol, Ben W. Willson, Melina Brown, Vicki Palacios, Talia Seidler, Anna Lene |
author_facet | Hunter, Kylie E. Webster, Angela C. Clarke, Mike Page, Matthew J. Libesman, Sol Godolphin, Peter J. Aberoumand, Mason Rydzewska, Larysa H. M. Wang, Rui Tan, Aidan C. Li, Wentao Mol, Ben W. Willson, Melina Brown, Vicki Palacios, Talia Seidler, Anna Lene |
author_sort | Hunter, Kylie E. |
collection | PubMed |
description | Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm and enhance data quality for individual participant data meta-analyses and how to conduct these checks. We aim to address this gap by developing a checklist of items for data quality checking and cleaning to be applied to individual participant data meta-analyses of randomised trials. This study will comprise three phases: 1) a scoping review to identify potential checklist items; 2) two e-Delphi survey rounds among an invited panel of experts followed by a consensus meeting; and 3) pilot testing and refinement of the checklist, including development of an accompanying R-markdown program to facilitate its uptake. |
format | Online Article Text |
id | pubmed-9553056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95530562022-10-12 Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study Hunter, Kylie E. Webster, Angela C. Clarke, Mike Page, Matthew J. Libesman, Sol Godolphin, Peter J. Aberoumand, Mason Rydzewska, Larysa H. M. Wang, Rui Tan, Aidan C. Li, Wentao Mol, Ben W. Willson, Melina Brown, Vicki Palacios, Talia Seidler, Anna Lene PLoS One Study Protocol Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm and enhance data quality for individual participant data meta-analyses and how to conduct these checks. We aim to address this gap by developing a checklist of items for data quality checking and cleaning to be applied to individual participant data meta-analyses of randomised trials. This study will comprise three phases: 1) a scoping review to identify potential checklist items; 2) two e-Delphi survey rounds among an invited panel of experts followed by a consensus meeting; and 3) pilot testing and refinement of the checklist, including development of an accompanying R-markdown program to facilitate its uptake. Public Library of Science 2022-10-11 /pmc/articles/PMC9553056/ /pubmed/36219622 http://dx.doi.org/10.1371/journal.pone.0275893 Text en © 2022 Hunter et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Study Protocol Hunter, Kylie E. Webster, Angela C. Clarke, Mike Page, Matthew J. Libesman, Sol Godolphin, Peter J. Aberoumand, Mason Rydzewska, Larysa H. M. Wang, Rui Tan, Aidan C. Li, Wentao Mol, Ben W. Willson, Melina Brown, Vicki Palacios, Talia Seidler, Anna Lene Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study |
title | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study |
title_full | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study |
title_fullStr | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study |
title_full_unstemmed | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study |
title_short | Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study |
title_sort | development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: protocol for a modified e-delphi study |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553056/ https://www.ncbi.nlm.nih.gov/pubmed/36219622 http://dx.doi.org/10.1371/journal.pone.0275893 |
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