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Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study
PURPOSE: To demonstrate through a controlled study whether the use of tranexamic acid in bariatric surgeries is effective for bleeding control. METHODS: Prospective, comparative, and double-blind study performed with patients from 18 to 65 years old submitted to bariatric surgery. The selected patie...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553071/ https://www.ncbi.nlm.nih.gov/pubmed/36228297 http://dx.doi.org/10.1590/acb370702 |
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author | de Brito, Roger Moura de Oliveira, Caio Márcio Barros Moura, Ed Carlos Rey Campelo, Giuliano Peixoto Lima, Roclides Castro Fe, Ciro Sousa de Moura Sousa, Tércio Maia de Oliveira, Eduardo José Silva Gomes Dibai, Almir Vieira Leal, Plínio da Cunha |
author_facet | de Brito, Roger Moura de Oliveira, Caio Márcio Barros Moura, Ed Carlos Rey Campelo, Giuliano Peixoto Lima, Roclides Castro Fe, Ciro Sousa de Moura Sousa, Tércio Maia de Oliveira, Eduardo José Silva Gomes Dibai, Almir Vieira Leal, Plínio da Cunha |
author_sort | de Brito, Roger Moura |
collection | PubMed |
description | PURPOSE: To demonstrate through a controlled study whether the use of tranexamic acid in bariatric surgeries is effective for bleeding control. METHODS: Prospective, comparative, and double-blind study performed with patients from 18 to 65 years old submitted to bariatric surgery. The selected patients received venous tranexamic acid (TXA) during the induction of anesthesia or not (CG). The anesthesia and thromboprophylaxis protocols were similar among the groups. For statistical analysis, the χ(2) and analysis of variance tests were performed at a significance level of p < 0.05, using the statistical program SPSS 21.0(®). RESULTS: Sixty-one patients were included in the study, 31 in the control group and 30 in the TXA group (GTXA). In the intraoperative period, the bleeding volume was greater in the CG than in the GTXA. In the postoperative period, the tranexamic acid group had a higher value hematocrit, absence of surgical reoperations due to bleeding complications, and shorter hospitalization time than the control group. CONCLUSIONS: The use of tranexamic acid was effective in reducing bleeding rates and of hospital stay length, in addition to demonstrating the clinical safety of its use, for not having been associated with any thromboembolic events. |
format | Online Article Text |
id | pubmed-9553071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-95530712022-10-17 Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study de Brito, Roger Moura de Oliveira, Caio Márcio Barros Moura, Ed Carlos Rey Campelo, Giuliano Peixoto Lima, Roclides Castro Fe, Ciro Sousa de Moura Sousa, Tércio Maia de Oliveira, Eduardo José Silva Gomes Dibai, Almir Vieira Leal, Plínio da Cunha Acta Cir Bras Clinical Investigation PURPOSE: To demonstrate through a controlled study whether the use of tranexamic acid in bariatric surgeries is effective for bleeding control. METHODS: Prospective, comparative, and double-blind study performed with patients from 18 to 65 years old submitted to bariatric surgery. The selected patients received venous tranexamic acid (TXA) during the induction of anesthesia or not (CG). The anesthesia and thromboprophylaxis protocols were similar among the groups. For statistical analysis, the χ(2) and analysis of variance tests were performed at a significance level of p < 0.05, using the statistical program SPSS 21.0(®). RESULTS: Sixty-one patients were included in the study, 31 in the control group and 30 in the TXA group (GTXA). In the intraoperative period, the bleeding volume was greater in the CG than in the GTXA. In the postoperative period, the tranexamic acid group had a higher value hematocrit, absence of surgical reoperations due to bleeding complications, and shorter hospitalization time than the control group. CONCLUSIONS: The use of tranexamic acid was effective in reducing bleeding rates and of hospital stay length, in addition to demonstrating the clinical safety of its use, for not having been associated with any thromboembolic events. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2022-10-10 /pmc/articles/PMC9553071/ /pubmed/36228297 http://dx.doi.org/10.1590/acb370702 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation de Brito, Roger Moura de Oliveira, Caio Márcio Barros Moura, Ed Carlos Rey Campelo, Giuliano Peixoto Lima, Roclides Castro Fe, Ciro Sousa de Moura Sousa, Tércio Maia de Oliveira, Eduardo José Silva Gomes Dibai, Almir Vieira Leal, Plínio da Cunha Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
title | Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
title_full | Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
title_fullStr | Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
title_full_unstemmed | Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
title_short | Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
title_sort | tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553071/ https://www.ncbi.nlm.nih.gov/pubmed/36228297 http://dx.doi.org/10.1590/acb370702 |
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