Pharmacophore modeling, docking and molecular dynamics simulation for identification of novel human protein kinase C beta (PKCβ) inhibitors

Protein kinase Cβ (PKCβ) is considered as an attractive molecular target for the treatment of COVID-19-related acute respiratory distress syndrome (ARDS). Several classes of inhibitors have been already identified. In this article, we developed and validated ligand-based PKCβ pharmacophore models ba...

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Detalles Bibliográficos
Autores principales: Starosyla, Sergiy A., Volynets, Galyna P., Protopopov, Mykola V., Bdzhola, Volodymyr G., Pashevin, Denis O., Polishchuk, Valentyna O., Kozak, Taisiia O., Stroi, Dmytro O., Dosenko, Victor E., Yarmoluk, Sergiy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553083/
https://www.ncbi.nlm.nih.gov/pubmed/36248344
http://dx.doi.org/10.1007/s11224-022-02075-y

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