Design, synthesis and biological evaluation of novel diarylpyridine derivatives as tubulin polymerisation inhibitors

A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evaluated for their in vitro antiproliferative activities. Among them, 10t showed remarkable antiproli...

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Detalles Bibliográficos
Autores principales: Yang, Shanbo, Wang, Chao, Shi, Lingyu, Chang, Jing, Zhang, Yujing, Meng, Jingsen, Liu, Wenjing, Zeng, Jun, Zhang, Renshuai, Shao, Yingchun, Xing, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553186/
https://www.ncbi.nlm.nih.gov/pubmed/36196773
http://dx.doi.org/10.1080/14756366.2022.2130284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553186/
https://www.ncbi.nlm.nih.gov/pubmed/36196773
http://dx.doi.org/10.1080/14756366.2022.2130284

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