Cargando…

Design, synthesis and biological evaluation of novel diarylpyridine derivatives as tubulin polymerisation inhibitors

A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evaluated for their in vitro antiproliferative activities. Among them, 10t showed remarkable antiproli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Shanbo, Wang, Chao, Shi, Lingyu, Chang, Jing, Zhang, Yujing, Meng, Jingsen, Liu, Wenjing, Zeng, Jun, Zhang, Renshuai, Shao, Yingchun, Xing, Dongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553186/ https://www.ncbi.nlm.nih.gov/pubmed/36196773 http://dx.doi.org/10.1080/14756366.2022.2130284

Ejemplares similares

Design, synthesis and biological evaluation of 9-aryl-5H-pyrido[4,3-b]indole derivatives as potential tubulin polymerization inhibitors
por: Shi, Lingyu, et al.
Publicado: (2022)

Advances in antitumor research of CA-4 analogs carrying quinoline scaffold
por: Wang, Chao, et al.
Publicado: (2022)

The role of NPC1L1 in cancer
por: Zhang, Renshuai, et al.
Publicado: (2022)

Research progress on antitumor activity of XRP44X and analogues as microtubule targeting agents
por: Wang, Chao, et al.
Publicado: (2023)

Recent Advances on the Role of ATGL in Cancer
por: Zhang, Renshuai, et al.
Publicado: (2022)

Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
por: Zeng, Jun, et al.
Publicado: (2022)

Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors
por: Wang, Guangcheng, et al.
Publicado: (2021)

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
por: Liu, Wenjing, et al.
Publicado: (2021)

Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors
por: Yang, Wei, et al.
Publicado: (2022)

First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor
por: Liu, Wenjing, et al.
Publicado: (2022)

Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors
por: Wang, Guangcheng, et al.
Publicado: (2021)

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors
por: Sardaru, Monica-Cornelia, et al.
Publicado: (2020)

Anticancer sulfonamide hybrids that inhibit bladder cancer cells growth and migration as tubulin polymerisation inhibitors
por: Liu, Jia, et al.
Publicado: (2019)

Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors
por: Fu, Dong-Jun, et al.
Publicado: (2020)

Design, synthesis and evaluation of dihydro-1H-indene derivatives as novel tubulin polymerisation inhibitors with anti-angiogenic and antitumor potency
por: Xu, Shengtao, et al.
Publicado: (2023)

Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activity
por: Shi, Xiao-Yi, et al.
Publicado: (2023)

Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents
por: Wang, Chao, et al.
Publicado: (2022)

PROTACs for BRDs proteins in cancer therapy: a review
por: Wang, Chao, et al.
Publicado: (2022)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation
por: Macabrey, Diane, et al.
Publicado: (2022)

Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents
por: Wang, Chao, et al.
Publicado: (2021)

In silico studies of diarylpyridine derivatives as novel HIV-1 NNRTIs using docking-based 3D-QSAR, molecular dynamics, and pharmacophore modeling approaches
por: Wan, Youlan, et al.
Publicado: (2018)

Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer
por: Ding, Lijuan, et al.
Publicado: (2021)

Synthesis of zirconocene complexes and their use in slurry-phase polymerisation of ethylene
por: Angpanitcharoen, Phakpoom, et al.
Publicado: (2021)

Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition
por: Duran, George E, et al.
Publicado: (2017)

Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges
por: Wang, Chao, et al.
Publicado: (2022)

Exploring Carbohydrates for Therapeutics: A Review on Future Directions
por: Wang, Jie, et al.
Publicado: (2021)

Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors
por: Mirzaei, Salimeh, et al.
Publicado: (2020)

Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities
por: Romagnoli, Romeo, et al.
Publicado: (2022)

Synthesis and characterisation of highly branched polyisoprene: exploiting the “Strathclyde route” in anionic polymerisation
por: Habibu, Shehu, et al.
Publicado: (2018)

Bioinspired crowding directs supramolecular polymerisation
por: Bäumer, Nils, et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents
por: Lu, Yan, et al.
Publicado: (2014)

Synthesis and biological evaluation of 2-aryl-benzimidazole derivatives of dehydroabietic acid as novel tubulin polymerization inhibitors
por: Miao, Ting-Ting, et al.
Publicado: (2018)

Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors
por: Zhang, Ling, et al.
Publicado: (2015)

Block Copolymers Based on Ethylene and Methacrylates Using a Combination of Catalytic Chain Transfer Polymerisation (CCTP) and Radical Polymerisation
por: Baffie, Florian, et al.
Publicado: (2021)

Synthesis of water-soluble surfactants using catalysed condensation polymerisation in green reaction media
por: Goddard, Amy R., et al.
Publicado: (2021)

YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways
por: Chen, Qun, et al.
Publicado: (2019)

The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site
por: Boichuk, Sergei, et al.
Publicado: (2021)

Actin polymerisation at the cytoplasmic face of eukaryotic nuclei
por: Münter, Sylvia, et al.
Publicado: (2006)

Polymerisation‐Induced Self‐Assembly of Graft Copolymers
por: Häkkinen, Satu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_joeka9abvgicu4v20v9n2gilao