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The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV

OBJECTIVE: Depression is common in people with HIV (PWH), yet little is known about the mechanisms contributing to depressive symptoms in PWH. Previous research across a range of populations has suggested a relationship between the neuropeptide oxytocin and depressive symptoms, with variable directi...

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Autores principales: Shortell, Destin D., Rubin, Leah H., Murphy, Aidan J., Cohen, Ronald A., Porges, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553265/
https://www.ncbi.nlm.nih.gov/pubmed/35980773
http://dx.doi.org/10.1097/PSY.0000000000001122
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author Shortell, Destin D.
Rubin, Leah H.
Murphy, Aidan J.
Cohen, Ronald A.
Porges, Eric C.
author_facet Shortell, Destin D.
Rubin, Leah H.
Murphy, Aidan J.
Cohen, Ronald A.
Porges, Eric C.
author_sort Shortell, Destin D.
collection PubMed
description OBJECTIVE: Depression is common in people with HIV (PWH), yet little is known about the mechanisms contributing to depressive symptoms in PWH. Previous research across a range of populations has suggested a relationship between the neuropeptide oxytocin and depressive symptoms, with variable directionality. This article investigated the association between peripheral oxytocin levels and depressive symptoms in PWH. METHODS: Unextracted oxytocin serum concentrations were assayed in 79 PWH (44% female, mean age = 34.35 [8.5], mean body mass index = 25.69 [5.46], mean CD4 = 516.60 [271.15]) who also completed the Center for Epidemiologic Studies Depression Scale (CES-D). CES-D items were evaluated in an exploratory factor analysis (EFA), and the relationships between oxytocin, total CES-D score, and the resulting EFA factors were analyzed with multivariate linear regressions conducted in R. Multiple regression models were used to adjust for age, sex, body mass index, CD4, and education. RESULTS: Contrary to hypothesized, higher peripheral oxytocin levels were associated with higher CES-D total scores with a small-to-moderate effect size (β = 0.26, p = .009). Following Bonferroni correction, oxytocin was not significantly associated with any of the five factors identified from the EFA: depressed affect, positive affect, appetite, cognitive symptoms, or perceived failure (p values > .042). Small effect sizes were found for the depressed affect (β = 0.22) and perceived failure (β = 0.21) factors (p values > .042). CONCLUSIONS: In a sample of predominately Black or African American individuals with HIV, higher oxytocin was associated with higher total depressive symptoms. In addition, this relationship was slightly stronger than those of specific depressive symptoms. These findings warrant further study into the role of oxytocin in mood symptoms within PWH.
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spelling pubmed-95532652022-10-19 The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV Shortell, Destin D. Rubin, Leah H. Murphy, Aidan J. Cohen, Ronald A. Porges, Eric C. Psychosom Med Original Articles OBJECTIVE: Depression is common in people with HIV (PWH), yet little is known about the mechanisms contributing to depressive symptoms in PWH. Previous research across a range of populations has suggested a relationship between the neuropeptide oxytocin and depressive symptoms, with variable directionality. This article investigated the association between peripheral oxytocin levels and depressive symptoms in PWH. METHODS: Unextracted oxytocin serum concentrations were assayed in 79 PWH (44% female, mean age = 34.35 [8.5], mean body mass index = 25.69 [5.46], mean CD4 = 516.60 [271.15]) who also completed the Center for Epidemiologic Studies Depression Scale (CES-D). CES-D items were evaluated in an exploratory factor analysis (EFA), and the relationships between oxytocin, total CES-D score, and the resulting EFA factors were analyzed with multivariate linear regressions conducted in R. Multiple regression models were used to adjust for age, sex, body mass index, CD4, and education. RESULTS: Contrary to hypothesized, higher peripheral oxytocin levels were associated with higher CES-D total scores with a small-to-moderate effect size (β = 0.26, p = .009). Following Bonferroni correction, oxytocin was not significantly associated with any of the five factors identified from the EFA: depressed affect, positive affect, appetite, cognitive symptoms, or perceived failure (p values > .042). Small effect sizes were found for the depressed affect (β = 0.22) and perceived failure (β = 0.21) factors (p values > .042). CONCLUSIONS: In a sample of predominately Black or African American individuals with HIV, higher oxytocin was associated with higher total depressive symptoms. In addition, this relationship was slightly stronger than those of specific depressive symptoms. These findings warrant further study into the role of oxytocin in mood symptoms within PWH. Lippincott Williams & Wilkins 2022-10 2022-08-16 /pmc/articles/PMC9553265/ /pubmed/35980773 http://dx.doi.org/10.1097/PSY.0000000000001122 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Articles
Shortell, Destin D.
Rubin, Leah H.
Murphy, Aidan J.
Cohen, Ronald A.
Porges, Eric C.
The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV
title The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV
title_full The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV
title_fullStr The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV
title_full_unstemmed The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV
title_short The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV
title_sort association between peripheral oxytocin levels and depressive symptoms in people with hiv
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553265/
https://www.ncbi.nlm.nih.gov/pubmed/35980773
http://dx.doi.org/10.1097/PSY.0000000000001122
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