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An inflammatory Signature of Glucose Impairment in Cystic Fibrosis

OBJECTIVE AND DESIGN: Cystic fibrosis-related diabetes (CFRD) is a severe complication associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Extensive inflammatory state in CF leads to pancreas damage and insulin resistance with consequent altered glucose tolerance and...

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Autores principales: Montemari, Anna Lisa, Manco, Melania, Fiocchi, Alessandro Giovanni, Bartoli, Manuela, Facchiano, Francesco, Tabolacci, Claudio, Scatigna, Maria, Ciciriello, Fabiana, Alghisi, Federico, Montemitro, Enza, Carsetti, Rita, Lucidi, Vincenzina, Fiscarelli, Ersilia Vita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553277/
https://www.ncbi.nlm.nih.gov/pubmed/36238762
http://dx.doi.org/10.2147/JIR.S365772
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author Montemari, Anna Lisa
Manco, Melania
Fiocchi, Alessandro Giovanni
Bartoli, Manuela
Facchiano, Francesco
Tabolacci, Claudio
Scatigna, Maria
Ciciriello, Fabiana
Alghisi, Federico
Montemitro, Enza
Carsetti, Rita
Lucidi, Vincenzina
Fiscarelli, Ersilia Vita
author_facet Montemari, Anna Lisa
Manco, Melania
Fiocchi, Alessandro Giovanni
Bartoli, Manuela
Facchiano, Francesco
Tabolacci, Claudio
Scatigna, Maria
Ciciriello, Fabiana
Alghisi, Federico
Montemitro, Enza
Carsetti, Rita
Lucidi, Vincenzina
Fiscarelli, Ersilia Vita
author_sort Montemari, Anna Lisa
collection PubMed
description OBJECTIVE AND DESIGN: Cystic fibrosis-related diabetes (CFRD) is a severe complication associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Extensive inflammatory state in CF leads to pancreas damage and insulin resistance with consequent altered glucose tolerance and CFRD development. The aim of the present study was to identify circulating levels of inflammatory markers specifically associated with impaired glucose tolerance (IGT) and overt CFRD in a sample of young adults with CF. MATERIALS AND METHODS: Sixty-four CF outpatients, without evident active pulmonary exacerbation, infectious and autoimmune diseases, were enrolled in the study and the levels of 45 inflammatory serum mediators were measured through x magnetic bead panel multiplex technology. RESULTS: Serum levels of PDGF-AA, CCL20/MIP3α, IFNα, CCL11/eotaxin, CXCL1/GROα, GMCSF, B7H1/PDL1, IL13, IL7, VEGF, and TGFα were all significantly (p<0.05) elevated in patients according to glycemic status and directly correlated with glycated hemoglobin and C-reactive protein levels. CONCLUSION: Our findings suggest that increased levels of specific circulating inflammatory mediators are directly associated with impaired glucose tolerance in CF patients, thus, potentially implicating them in CFRD pathogenesis and warranting larger longitudinal studies to validate their monitoring as predictor of CFRD onset.
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spelling pubmed-95532772022-10-12 An inflammatory Signature of Glucose Impairment in Cystic Fibrosis Montemari, Anna Lisa Manco, Melania Fiocchi, Alessandro Giovanni Bartoli, Manuela Facchiano, Francesco Tabolacci, Claudio Scatigna, Maria Ciciriello, Fabiana Alghisi, Federico Montemitro, Enza Carsetti, Rita Lucidi, Vincenzina Fiscarelli, Ersilia Vita J Inflamm Res Original Research OBJECTIVE AND DESIGN: Cystic fibrosis-related diabetes (CFRD) is a severe complication associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Extensive inflammatory state in CF leads to pancreas damage and insulin resistance with consequent altered glucose tolerance and CFRD development. The aim of the present study was to identify circulating levels of inflammatory markers specifically associated with impaired glucose tolerance (IGT) and overt CFRD in a sample of young adults with CF. MATERIALS AND METHODS: Sixty-four CF outpatients, without evident active pulmonary exacerbation, infectious and autoimmune diseases, were enrolled in the study and the levels of 45 inflammatory serum mediators were measured through x magnetic bead panel multiplex technology. RESULTS: Serum levels of PDGF-AA, CCL20/MIP3α, IFNα, CCL11/eotaxin, CXCL1/GROα, GMCSF, B7H1/PDL1, IL13, IL7, VEGF, and TGFα were all significantly (p<0.05) elevated in patients according to glycemic status and directly correlated with glycated hemoglobin and C-reactive protein levels. CONCLUSION: Our findings suggest that increased levels of specific circulating inflammatory mediators are directly associated with impaired glucose tolerance in CF patients, thus, potentially implicating them in CFRD pathogenesis and warranting larger longitudinal studies to validate their monitoring as predictor of CFRD onset. Dove 2022-10-10 /pmc/articles/PMC9553277/ /pubmed/36238762 http://dx.doi.org/10.2147/JIR.S365772 Text en © 2022 Montemari et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Montemari, Anna Lisa
Manco, Melania
Fiocchi, Alessandro Giovanni
Bartoli, Manuela
Facchiano, Francesco
Tabolacci, Claudio
Scatigna, Maria
Ciciriello, Fabiana
Alghisi, Federico
Montemitro, Enza
Carsetti, Rita
Lucidi, Vincenzina
Fiscarelli, Ersilia Vita
An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
title An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
title_full An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
title_fullStr An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
title_full_unstemmed An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
title_short An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
title_sort inflammatory signature of glucose impairment in cystic fibrosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553277/
https://www.ncbi.nlm.nih.gov/pubmed/36238762
http://dx.doi.org/10.2147/JIR.S365772
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