Cargando…

Molecular Changes in Chronic Myeloid Leukemia During Tyrosine Kinase Inhibitors Treatment. Focus on Immunological Pathways

INTRODUCTION: The aim of our research was to investigate changes in the molecular background of the immune response in the chronic phase (CP) of chronic myeloid leukaemia (CML) during treatment with tyrosine kinase inhibitors (TKIs). METHODS: Global gene and miRNA expression profiles were assessed u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Janowski, Michał, Ulańczyk, Zofia, Łuczkowska, Karolina, Sobuś, Anna, Rogińska, Dorota, Pius-Sadowska, Ewa, Gniot, Michał, Kozłowski, Krzysztof, Lewandowski, Krzysztof, Helbig, Grzegorz, Machaliński, Bogusław, Paczkowska, Edyta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553433/ https://www.ncbi.nlm.nih.gov/pubmed/36238136 http://dx.doi.org/10.2147/OTT.S371847

Ejemplares similares

Molecular Mechanisms of Bortezomib Action: Novel Evidence for the miRNA–mRNA Interaction Involvement
por: Łuczkowska, Karolina, et al.
Publicado: (2020)

Effect of Bortezomib on Global Gene Expression in PC12-Derived Nerve Cells
por: Łuczkowska, Karolina, et al.
Publicado: (2020)

Novel design of (PEG-ylated)PAMAM-based nanoparticles for sustained delivery of BDNF to neurotoxin-injured differentiated neuroblastoma cells
por: Dąbkowska, Maria, et al.
Publicado: (2020)

Apoptosis Evaluation in Circulating CD34+-Enriched Hematopoietic Stem and Progenitor Cells in Patients with Abnormally Increased Production of Endogenous Glucocorticoids in Course of Cushing’s Syndrome
por: Kawa, Miłosz P., et al.
Publicado: (2022)

CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 Course
por: Pius-Sadowska, Ewa, et al.
Publicado: (2022)

The role of the electrokinetic charge of neurotrophis-based nanocarriers: protein distribution, toxicity, and oxidative stress in in vitro setting
por: Dąbkowska, Maria, et al.
Publicado: (2021)

Differential Secretion of Angiopoietic Factors and Expression of MicroRNA in Umbilical Cord Blood from Healthy Appropriate-For-Gestational-Age Preterm and Term Newborns—in Search of Biomarkers of Angiogenesis-Related Processes in Preterm Birth
por: Gródecka-Szwajkiewicz, Dorota, et al.
Publicado: (2020)

The Impact of Growth Hormone Therapy on the Apoptosis Assessment in CD34+ Hematopoietic Cells from Children with Growth Hormone Deficiency
por: Kawa, Miłosz Piotr, et al.
Publicado: (2017)

The Potential Role of Proinflammatory Cytokines and Complement Components in the Development of Drug-Induced Neuropathy in Patients with Multiple Myeloma
por: Łuczkowska, Karolina, et al.
Publicado: (2021)

Comparative Analysis of Global Gene Expression and Complement Components Levels in Umbilical Cord Blood from Preterm and Term Neonates: Implications for Significant Downregulation of Immune Response Pathways related to Prematurity
por: Gródecka-Szwajkiewicz, Dorota, et al.
Publicado: (2020)

Repeated Application of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells—Focus on Immunological Pathways in Patients with ALS
por: Baumert, Bartłomiej, et al.
Publicado: (2020)

Humoral Activity of Cord Blood-Derived Stem/Progenitor Cells: Implications for Stem Cell-Based Adjuvant Therapy of Neurodegenerative Disorders
por: Paczkowska, Edyta, et al.
Publicado: (2013)

Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice
por: Lejkowska, Renata, et al.
Publicado: (2019)

Local and Systemic Humoral Response to Autologous Lineage-Negative Cells Intrathecal Administration in ALS Patients
por: Baumert, Bartłomiej, et al.
Publicado: (2020)

Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury
por: Machalińska, Anna, et al.
Publicado: (2015)

Essential thrombocythaemia progression to the fibrotic phase is associated with a decrease in JAK2 and PDL1 levels
por: Lewandowski, Krzysztof, et al.
Publicado: (2022)

Effects of growth hormone therapeutic supplementation on hematopoietic stem/progenitor cells in children with growth hormone deficiency: focus on proliferation and differentiation capabilities
por: Kawa, M. P., et al.
Publicado: (2015)

Bortezomib-Induced Epigenetic Alterations in Nerve Cells: Focus on the Mechanisms Contributing to the Peripheral Neuropathy Development
por: Łuczkowska, Karolina, et al.
Publicado: (2022)

Associations of MicroRNAs, Angiogenesis-Regulating Factors and CFH Y402H Polymorphism—An Attempt to Search for Systemic Biomarkers in Age-Related Macular Degeneration
por: Ulańczyk, Zofia, et al.
Publicado: (2019)

Adjuvant Lineage-Negative Cell Therapy as a Potential Silencer of the Complement-Mediated Immune System in ALS Patients
por: Sobuś, Anna, et al.
Publicado: (2021)

Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model
por: Rogińska, Dorota, et al.
Publicado: (2017)

The Interplay Between Systemic Inflammatory Factors and MicroRNAs in Age-Related Macular Degeneration
por: Litwińska, Zofia, et al.
Publicado: (2019)

JAK2V617F variant allele frequency, non-driver mutations, single-nucleotide variants and polycythemia vera outcome
por: Kanduła, Zuzanna, et al.
Publicado: (2022)

Electrostatic complex of neurotrophin 4 with dendrimer nanoparticles: controlled release of protein in vitro and in vivo
por: Dąbkowska, Maria, et al.
Publicado: (2019)

Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid Arthritis
por: Piotrowska, Katarzyna, et al.
Publicado: (2020)

Hodgkin Lymphoma as a Secondary Neoplasm During Therapy for Chronic Myeloid Leukaemia: Case Report and Review of the Literature
por: Paczkowska, Edyta, et al.
Publicado: (2021)

Novel Evidence of the Increase in Angiogenic Factor Plasma Levels after Lineage-Negative Stem/Progenitor Cell Intracoronary Infusion in Patients with Acute Myocardial Infarction
por: Baumert, Bartłomiej, et al.
Publicado: (2019)

The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction
por: Peregud-Pogorzelska, Małgorzata, et al.
Publicado: (2020)

Humoral Influence of Repeated Lineage-Negative Stem/Progenitor Cell Administration on Articulatory Functions in ALS Patients
por: Sobuś, Anna, et al.
Publicado: (2020)

IgA-Based Secretory Response in Tears of COVID-19 Patients: A Potential Biomarker of Pro-Inflammatory State in Course of SARS-CoV-2 Infection
por: Niedźwiedź, Anna, et al.
Publicado: (2022)

Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
por: Łuczkowska, Karolina, et al.
Publicado: (2021)

High molecular risk variants, severe thrombocytopenia and large unstained cells count affect the outcome in primary myelofibrosis
por: Kanduła, Zuzanna, et al.
Publicado: (2023)

Neural stem/progenitor cells circulating in peripheral blood of patients with neovascular form of AMD: a novel view on pathophysiology
por: Machalińska, Anna, et al.
Publicado: (2011)

Vitamin D as a Potential Player in Immunologic Control over Multiple Myeloma Cells: Implications for Adjuvant Therapies
por: Kulig, Piotr, et al.
Publicado: (2022)

Influence of Lineage-Negative Stem Cell Therapy on Articulatory Functions in ALS Patients
por: Pawlukowska, Wioletta, et al.
Publicado: (2019)

Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis
por: Pius‐Sadowska, Ewa, et al.
Publicado: (2021)

Effects of Angiotensin-Converting Enzyme Inhibition on Circulating Endothelial Progenitor Cells in Patients with Acute Ischemic Stroke
por: Gołąb-Janowska, Monika, et al.
Publicado: (2018)

Erratum to “Effects of Angiotensin-Converting Enzyme Inhibition on Circulating Endothelial Progenitor Cells in Patients with Acute Ischemic Stroke”
por: Gołąb-Janowska, Monika, et al.
Publicado: (2020)

Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells
por: Łuczkowska, Karolina, et al.
Publicado: (2022)

Case of Patient with AML with Complex Karyotype including Ultra-Rare t(4;8)(q32;q13), t(4;11)(q21;p15) and Familial Aggregation of Myeloid Malignancies
por: Milczarek, Sławomir, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_plk7q61p6fngtidj2lbvta32bv