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Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation

BACKGROUND: To investigate the characteristics of sleep cycle in children with severe acute bronchopneumonia treated with invasive mechanical ventilation at different sedation depths. METHODS: We included 35 pediatric patients with severe acute bronchopneumonia treated using mechanical ventilation i...

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Autores principales: Zhao, XueShan, Yan, JingLi, Wu, Bo, Zheng, Duo, Fang, Xiuying, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553625/
https://www.ncbi.nlm.nih.gov/pubmed/36224544
http://dx.doi.org/10.1186/s12887-022-03658-8
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author Zhao, XueShan
Yan, JingLi
Wu, Bo
Zheng, Duo
Fang, Xiuying
Xu, Wei
author_facet Zhao, XueShan
Yan, JingLi
Wu, Bo
Zheng, Duo
Fang, Xiuying
Xu, Wei
author_sort Zhao, XueShan
collection PubMed
description BACKGROUND: To investigate the characteristics of sleep cycle in children with severe acute bronchopneumonia treated with invasive mechanical ventilation at different sedation depths. METHODS: We included 35 pediatric patients with severe acute bronchopneumonia treated using mechanical ventilation in Pediatric Intensive Care Unit of Shengjing Hospital of China Medical University. They were divided into deep sedation group (n = 21; ramsay score 5–6) and light sedation group (n = 14; ramsay score3-4) based on sedation depth achieved during mechanical ventilation. Long-term video electroencephalography (EEG) monitoring was performed within the first 24 h after starting mechanical ventilation and after weaning from mechanical ventilation and discontinuing sedatives and analgesics. The results were analyzed and compared with those of normal children to analyze changes in sleep cycle characteristics at different sedation depths and mechanical ventilation stages. RESULTS: There were 29 cases altered sleep architecture. The deep sedation group had a significantly higher incidence of sleep architecture altered, total sleep duration, and non-rapid eye movement sleep-1 (NREM-1) loss incidence than the light sedation group. Moreover, the deep sedation group had a significantly lower awakening number and rapid eye movement sleep (REM) percentage than the light sedation group. The sleep cycle returned to normal in 27 (77%) patients without NREM-1 or REM sleep loss. CONCLUSIONS: Deep sedation during mechanical ventilation allows longer total sleep duration, fewer awakenings, and an increased deep sleep proportion, but sleep architecture is severely altered. After weaning from mechanical ventilation and sedative discontinuation, lightly sedated children exhibit better sleep recovery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03658-8.
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spelling pubmed-95536252022-10-12 Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation Zhao, XueShan Yan, JingLi Wu, Bo Zheng, Duo Fang, Xiuying Xu, Wei BMC Pediatr Research Article BACKGROUND: To investigate the characteristics of sleep cycle in children with severe acute bronchopneumonia treated with invasive mechanical ventilation at different sedation depths. METHODS: We included 35 pediatric patients with severe acute bronchopneumonia treated using mechanical ventilation in Pediatric Intensive Care Unit of Shengjing Hospital of China Medical University. They were divided into deep sedation group (n = 21; ramsay score 5–6) and light sedation group (n = 14; ramsay score3-4) based on sedation depth achieved during mechanical ventilation. Long-term video electroencephalography (EEG) monitoring was performed within the first 24 h after starting mechanical ventilation and after weaning from mechanical ventilation and discontinuing sedatives and analgesics. The results were analyzed and compared with those of normal children to analyze changes in sleep cycle characteristics at different sedation depths and mechanical ventilation stages. RESULTS: There were 29 cases altered sleep architecture. The deep sedation group had a significantly higher incidence of sleep architecture altered, total sleep duration, and non-rapid eye movement sleep-1 (NREM-1) loss incidence than the light sedation group. Moreover, the deep sedation group had a significantly lower awakening number and rapid eye movement sleep (REM) percentage than the light sedation group. The sleep cycle returned to normal in 27 (77%) patients without NREM-1 or REM sleep loss. CONCLUSIONS: Deep sedation during mechanical ventilation allows longer total sleep duration, fewer awakenings, and an increased deep sleep proportion, but sleep architecture is severely altered. After weaning from mechanical ventilation and sedative discontinuation, lightly sedated children exhibit better sleep recovery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03658-8. BioMed Central 2022-10-12 /pmc/articles/PMC9553625/ /pubmed/36224544 http://dx.doi.org/10.1186/s12887-022-03658-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhao, XueShan
Yan, JingLi
Wu, Bo
Zheng, Duo
Fang, Xiuying
Xu, Wei
Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
title Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
title_full Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
title_fullStr Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
title_full_unstemmed Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
title_short Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
title_sort sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553625/
https://www.ncbi.nlm.nih.gov/pubmed/36224544
http://dx.doi.org/10.1186/s12887-022-03658-8
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