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Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature
Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who develop...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553724/ https://www.ncbi.nlm.nih.gov/pubmed/36249573 http://dx.doi.org/10.1155/2022/1233522 |
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author | Tsubouchi, Syoko Mizuuchi, Takahiro Yamamoto, Yusuke Fujimori, Daiki Ishii, Kayo Tago, Mayu Kato, Eri Mori, Hiroaki Hayashi, Haeru Tahara, Koichiro Sawada, Tetsuji |
author_facet | Tsubouchi, Syoko Mizuuchi, Takahiro Yamamoto, Yusuke Fujimori, Daiki Ishii, Kayo Tago, Mayu Kato, Eri Mori, Hiroaki Hayashi, Haeru Tahara, Koichiro Sawada, Tetsuji |
author_sort | Tsubouchi, Syoko |
collection | PubMed |
description | Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association. |
format | Online Article Text |
id | pubmed-9553724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95537242022-10-13 Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature Tsubouchi, Syoko Mizuuchi, Takahiro Yamamoto, Yusuke Fujimori, Daiki Ishii, Kayo Tago, Mayu Kato, Eri Mori, Hiroaki Hayashi, Haeru Tahara, Koichiro Sawada, Tetsuji Case Rep Rheumatol Case Report Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association. Hindawi 2022-09-20 /pmc/articles/PMC9553724/ /pubmed/36249573 http://dx.doi.org/10.1155/2022/1233522 Text en Copyright © 2022 Syoko Tsubouchi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Tsubouchi, Syoko Mizuuchi, Takahiro Yamamoto, Yusuke Fujimori, Daiki Ishii, Kayo Tago, Mayu Kato, Eri Mori, Hiroaki Hayashi, Haeru Tahara, Koichiro Sawada, Tetsuji Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
title | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
title_full | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
title_fullStr | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
title_full_unstemmed | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
title_short | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
title_sort | nephrotic syndrome as an extramuscular manifestation of anti-ej antibody-positive dermatomyositis: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553724/ https://www.ncbi.nlm.nih.gov/pubmed/36249573 http://dx.doi.org/10.1155/2022/1233522 |
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