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SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture

BACKGROUND: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imag...

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Autores principales: Van der Heiden, K., Barrett, H. E., Meester, E. J., van Gaalen, K., Krenning, B. J., Beekman, F. J., de Blois, E., de Swart, J., Verhagen, H. J. M., van der Lugt, A., Norenberg, J. P., de Jong, M., Bernsen, M. R., Gijsen, F. J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553768/
https://www.ncbi.nlm.nih.gov/pubmed/34318395
http://dx.doi.org/10.1007/s12350-021-02745-0
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author Van der Heiden, K.
Barrett, H. E.
Meester, E. J.
van Gaalen, K.
Krenning, B. J.
Beekman, F. J.
de Blois, E.
de Swart, J.
Verhagen, H. J. M.
van der Lugt, A.
Norenberg, J. P.
de Jong, M.
Bernsen, M. R.
Gijsen, F. J. H.
author_facet Van der Heiden, K.
Barrett, H. E.
Meester, E. J.
van Gaalen, K.
Krenning, B. J.
Beekman, F. J.
de Blois, E.
de Swart, J.
Verhagen, H. J. M.
van der Lugt, A.
Norenberg, J. P.
de Jong, M.
Bernsen, M. R.
Gijsen, F. J. H.
author_sort Van der Heiden, K.
collection PubMed
description BACKGROUND: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. METHODS: Human carotid plaque segments, obtained from endarterectomy, were incubated in [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt), targeting Leukocyte Function-associated Antigen-1 (LFA-1) on leukocytes. By performing SPECT/CT, both inflammation from DANBIRT uptake and calcification from CT imaging were assessed. Plaque phenotype was classified using histology. RESULTS: On a total plaque level, comparable levels of calcification volume existed with different degrees of inflammation and vice versa. On a segment level, an inverse relationship between calcification volume and inflammation was evident in highly calcified segments, which classify as fibrocalcific, stable plaque segments. In contrast, segments with little or no calcification presented with a moderate to high degree of inflammation, often coinciding with the more dangerous fibrous cap atheroma phenotype. CONCLUSION: Calcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12350-021-02745-0.
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spelling pubmed-95537682022-10-13 SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture Van der Heiden, K. Barrett, H. E. Meester, E. J. van Gaalen, K. Krenning, B. J. Beekman, F. J. de Blois, E. de Swart, J. Verhagen, H. J. M. van der Lugt, A. Norenberg, J. P. de Jong, M. Bernsen, M. R. Gijsen, F. J. H. J Nucl Cardiol Original Article BACKGROUND: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. METHODS: Human carotid plaque segments, obtained from endarterectomy, were incubated in [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt), targeting Leukocyte Function-associated Antigen-1 (LFA-1) on leukocytes. By performing SPECT/CT, both inflammation from DANBIRT uptake and calcification from CT imaging were assessed. Plaque phenotype was classified using histology. RESULTS: On a total plaque level, comparable levels of calcification volume existed with different degrees of inflammation and vice versa. On a segment level, an inverse relationship between calcification volume and inflammation was evident in highly calcified segments, which classify as fibrocalcific, stable plaque segments. In contrast, segments with little or no calcification presented with a moderate to high degree of inflammation, often coinciding with the more dangerous fibrous cap atheroma phenotype. CONCLUSION: Calcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12350-021-02745-0. Springer International Publishing 2021-07-27 2022 /pmc/articles/PMC9553768/ /pubmed/34318395 http://dx.doi.org/10.1007/s12350-021-02745-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Van der Heiden, K.
Barrett, H. E.
Meester, E. J.
van Gaalen, K.
Krenning, B. J.
Beekman, F. J.
de Blois, E.
de Swart, J.
Verhagen, H. J. M.
van der Lugt, A.
Norenberg, J. P.
de Jong, M.
Bernsen, M. R.
Gijsen, F. J. H.
SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
title SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
title_full SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
title_fullStr SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
title_full_unstemmed SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
title_short SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
title_sort spect/ct imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553768/
https://www.ncbi.nlm.nih.gov/pubmed/34318395
http://dx.doi.org/10.1007/s12350-021-02745-0
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