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Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury
Serum concentrations of free thiols (key components of the extracellular antioxidant machinery) reflect the overall redox status of the human body. The objective of this exploratory study was to determine the concentrations of serum free thiols in the acute phase after traumatic brain injury (TBI) a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553822/ https://www.ncbi.nlm.nih.gov/pubmed/35776194 http://dx.doi.org/10.1007/s00415-022-11240-6 |
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author | Visser, Koen van der Horn, Harm Jan Bourgonje, Arno R. Jacobs, Bram de Borst, Martin H. Vos, Pieter E. Bulthuis, Marian L. C. van Goor, Harry van der Naalt, Joukje |
author_facet | Visser, Koen van der Horn, Harm Jan Bourgonje, Arno R. Jacobs, Bram de Borst, Martin H. Vos, Pieter E. Bulthuis, Marian L. C. van Goor, Harry van der Naalt, Joukje |
author_sort | Visser, Koen |
collection | PubMed |
description | Serum concentrations of free thiols (key components of the extracellular antioxidant machinery) reflect the overall redox status of the human body. The objective of this exploratory study was to determine the concentrations of serum free thiols in the acute phase after traumatic brain injury (TBI) and their association with long-term outcome. In this observational cohort study, patients with TBI of various severity were included from a biobank of prospectively enrolled TBI patients. Further eligibility criteria included an available blood sample and head computed tomography data, obtained within 24 h of injury, as well as a functional outcome assessment (Glasgow Outcome Scale Extended (GOSE)) at 6 months post-injury. Serum free thiol concentrations were markedly lower in patients with TBI (n = 77) compared to healthy controls (n = 55) (mean ± standard deviation; 210.3 ± 63.3 vs. 301.8 ± 23.9 μM, P < 0.001) indicating increased oxidative stress. Concentrations of serum free thiols were higher in patients with complete functional recovery (GOSE = 8) than in patients with incomplete recovery (GOSE < 8) (median [interquartile range]; 235.7 [205.1–271.9] vs. 205.2 [173–226.7] μM, P = 0.016), suggesting that patients with good recovery experience less oxidative stress in the acute phase after TBI or have better redox function. Acute TBI is accompanied by a markedly lower concentration of serum free thiols compared to healthy controls indicating that serum free thiols may be a novel biomarker of TBI. Future studies are warranted to validate our findings and explore the clinical applicability and prognostic capability of this candidate-biomarker. |
format | Online Article Text |
id | pubmed-9553822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-95538222022-10-13 Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury Visser, Koen van der Horn, Harm Jan Bourgonje, Arno R. Jacobs, Bram de Borst, Martin H. Vos, Pieter E. Bulthuis, Marian L. C. van Goor, Harry van der Naalt, Joukje J Neurol Original Communication Serum concentrations of free thiols (key components of the extracellular antioxidant machinery) reflect the overall redox status of the human body. The objective of this exploratory study was to determine the concentrations of serum free thiols in the acute phase after traumatic brain injury (TBI) and their association with long-term outcome. In this observational cohort study, patients with TBI of various severity were included from a biobank of prospectively enrolled TBI patients. Further eligibility criteria included an available blood sample and head computed tomography data, obtained within 24 h of injury, as well as a functional outcome assessment (Glasgow Outcome Scale Extended (GOSE)) at 6 months post-injury. Serum free thiol concentrations were markedly lower in patients with TBI (n = 77) compared to healthy controls (n = 55) (mean ± standard deviation; 210.3 ± 63.3 vs. 301.8 ± 23.9 μM, P < 0.001) indicating increased oxidative stress. Concentrations of serum free thiols were higher in patients with complete functional recovery (GOSE = 8) than in patients with incomplete recovery (GOSE < 8) (median [interquartile range]; 235.7 [205.1–271.9] vs. 205.2 [173–226.7] μM, P = 0.016), suggesting that patients with good recovery experience less oxidative stress in the acute phase after TBI or have better redox function. Acute TBI is accompanied by a markedly lower concentration of serum free thiols compared to healthy controls indicating that serum free thiols may be a novel biomarker of TBI. Future studies are warranted to validate our findings and explore the clinical applicability and prognostic capability of this candidate-biomarker. Springer Berlin Heidelberg 2022-07-01 2022 /pmc/articles/PMC9553822/ /pubmed/35776194 http://dx.doi.org/10.1007/s00415-022-11240-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Communication Visser, Koen van der Horn, Harm Jan Bourgonje, Arno R. Jacobs, Bram de Borst, Martin H. Vos, Pieter E. Bulthuis, Marian L. C. van Goor, Harry van der Naalt, Joukje Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
title | Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
title_full | Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
title_fullStr | Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
title_full_unstemmed | Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
title_short | Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
title_sort | acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553822/ https://www.ncbi.nlm.nih.gov/pubmed/35776194 http://dx.doi.org/10.1007/s00415-022-11240-6 |
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