Cargando…

BRD4 Silencing Protects Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting TLR4/NF-κB and Activating Nrf2-HO-1 Pathways

BACKGROUND: Heart failure is a critical health problem worldwide, and cardiac hypertrophy is an important characteristic of heart failure. Bromodomain-containing protein 4 (BRD4) is involved in various cellular processes, including cardiac hypertrophy. This study aimed to investigate the mechanism u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Ming, Luo, Jun, Zhu, Xi, Wu, Yingbiao, Li, Xinming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553838/ https://www.ncbi.nlm.nih.gov/pubmed/36247184 http://dx.doi.org/10.1155/2022/8372707

Ejemplares similares

LOXL2 silencing suppresses angiotensin II-induced cardiac hypertrophy through the EMT process and TGF-β1/Smad3/NF-κB pathway
por: Luo, Jun, et al.
Publicado: (2022)

Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
por: Mohamed, Maged E., et al.
Publicado: (2020)

A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways
por: Ibrahim, Kawther Magdy, et al.
Publicado: (2023)

β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
por: Younis, Nancy S.
Publicado: (2022)

Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways
por: Morsy, Mohamed A., et al.
Publicado: (2022)

Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2/HO1 and HMGB1/TLR4/NF-κB pathways
por: Shams, Shams Gamal Eldin, et al.
Publicado: (2022)

Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in mice
por: Xu, Mingyue, et al.
Publicado: (2020)

Maackiain Protects the Kidneys of Type 2 Diabetic Rats via Modulating the Nrf2/HO-1 and TLR4/NF-κB/Caspase-3 Pathways
por: Guo, Jiahong, et al.
Publicado: (2021)

Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF‐κB and Nrf2/HO‐1/GPX4 pathways to reduce inflammation and ferroptosis
por: Shi, Pei, et al.
Publicado: (2023)

Renal Ischemia/Reperfusion Mitigation via Geraniol: The Role of Nrf-2/HO-1/NQO-1 and TLR2,4/MYD88/NFκB Pathway
por: Mohamed, Maged E., et al.
Publicado: (2022)

Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade
por: Rahman, Md Saifur, et al.
Publicado: (2021)

JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis
por: Lee, Min Bum, et al.
Publicado: (2017)

Effects of Dietary Resveratrol Supplementation on Growth Performance and Anti-Inflammatory Ability in Ducks (Anas platyrhynchos) through the Nrf2/HO-1 and TLR4/NF-κB Signaling Pathways
por: Yang, Hao, et al.
Publicado: (2021)

Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling
por: Atwa, Ahmed M., et al.
Publicado: (2022)

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway
por: Zheng, Bin, et al.
Publicado: (2021)

BRD4 jump-starts transcription after mitotic silencing
por: Voigt, Philipp, et al.
Publicado: (2011)

Function of BRD4 in the pathogenesis of high glucose-induced cardiac hypertrophy
por: Wang, Qian, et al.
Publicado: (2019)

BGN/TLR4/NF-κB Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells
por: Huang, Hsiang-Chi, et al.
Publicado: (2020)

Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats
por: Mahmoud, Ayman M., et al.
Publicado: (2019)

Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia
por: Rong, Shikuo, et al.
Publicado: (2022)

Daeshiho-tang attenuates inflammatory response and oxidative stress in LPS-stimulated macrophages by regulating TLR4/MyD88, NF-κB, MAPK, and Nrf2/HO-1 pathways
por: Oh, Yong Jin, et al.
Publicado: (2023)

BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer
por: Hajmirza, Azadeh, et al.
Publicado: (2018)

Stevioside attenuates osteoarthritis via regulating Nrf2/HO-1/NF-κB pathway
por: Wu, Jia, et al.
Publicado: (2022)

Potential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis
por: Li, Shi-jie, et al.
Publicado: (2023)

Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways
por: Huang, Xiao, et al.
Publicado: (2019)

Cordyceps cicadae Mycelia Ameliorate Cisplatin-Induced Acute Kidney Injury by Suppressing the TLR4/NF-κB/MAPK and Activating the HO-1/Nrf2 and Sirt-1/AMPK Pathways in Mice
por: Deng, Jeng-Shyan, et al.
Publicado: (2020)

Lactobacillus plantarum Lp2 improved LPS-induced liver injury through the TLR-4/MAPK/NFκB and Nrf2-HO-1/CYP2E1 pathways in mice
por: Chen, Yiying, et al.
Publicado: (2022)

TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling
por: Lin, Ke, et al.
Publicado: (2020)

Glaucocalyxin A Attenuates Allergic Responses by Inhibiting Mast Cell Degranulation through p38MAPK/NrF2/HO-1 and HMGB1/TLR4/NF-κB Signaling Pathways
por: Piao, Yihua, et al.
Publicado: (2021)

Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
por: Balaha, Mohamed F., et al.
Publicado: (2023)

Modulation of TLR4/NFκB Pathways in Autoimmune Myocarditis
por: Interdonato, Livia, et al.
Publicado: (2023)

BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC
por: Shi, Liu, et al.
Publicado: (2021)

Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice
por: Qi, Shuang, et al.
Publicado: (2020)

Tanshinol ameliorates CCl(4)-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
por: Wang, Rong, et al.
Publicado: (2018)

Loganin Inhibits Angiotensin II–Induced Cardiac Hypertrophy Through the JAK2/STAT3 and NF-κB Signaling Pathways
por: Xu, Jia-jia, et al.
Publicado: (2021)

Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR‐4/NF‐κB and AMPK/Nrf2 signalling pathways
por: Zhang, Kefeng, et al.
Publicado: (2020)

Serum NF-κBp65, TLR4 as Biomarker for Diagnosis of Preeclampsia
por: Litang, Zhao, et al.
Publicado: (2017)

Effects of Ginkgo biloba leaf extract on local renin-angiotensin system through TLR4/NF-κB pathway in cardiac myocyte
por: Jiang, Hua, et al.
Publicado: (2017)

Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway
por: Ma, Tianwen, et al.
Publicado: (2022)

Knockdown of ANGPTL2 Protects Renal Tubular Epithelial Cells Against Hypoxia/Reoxygenation-Induced Injury via Suppressing TLR4/NF-κB Signaling Pathway and Activating Nrf2/HO-1 Signaling Pathway
por: Xiang, Heli, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kovhskn10slr9u2bjdn3leq1q1