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Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma

Objective: This study aimed to analyze the efficacy of autologous peripheral blood stem cell transplantation for high-risk neuroblastoma in China. Methods: The data of 90 high-risk neuroblastoma patients treated with the CCCG-NB 2015 regimen were reviewed. The baseline clinicopathological characteri...

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Autores principales: Yan, Jin, Jie, Li, Jiaxing, Yang, Yanna, Cao, Zhanglin, Li, Zhongyuan, Li, Daowei, Wang, Guangzong, Zhao, Benfu, Zhong, Jie, Yan, Qiang, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553861/
https://www.ncbi.nlm.nih.gov/pubmed/36237985
http://dx.doi.org/10.7150/ijms.76305
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author Yan, Jin
Jie, Li
Jiaxing, Yang
Yanna, Cao
Zhanglin, Li
Zhongyuan, Li
Daowei, Wang
Guangzong, Zhao
Benfu, Zhong
Jie, Yan
Qiang, Zhao
author_facet Yan, Jin
Jie, Li
Jiaxing, Yang
Yanna, Cao
Zhanglin, Li
Zhongyuan, Li
Daowei, Wang
Guangzong, Zhao
Benfu, Zhong
Jie, Yan
Qiang, Zhao
author_sort Yan, Jin
collection PubMed
description Objective: This study aimed to analyze the efficacy of autologous peripheral blood stem cell transplantation for high-risk neuroblastoma in China. Methods: The data of 90 high-risk neuroblastoma patients treated with the CCCG-NB 2015 regimen were reviewed. The baseline clinicopathological characteristics and prognosis were analyzed and compared. In addition, the prognoses of tandem autologous stem cell transplantation and single autologous stem cell transplantation groups were compared. Results: The results of survival analysis showed that autologous peripheral blood stem cell transplantation based on this pretreatment regimen significantly improved the prognosis of children in the high-risk group. The 3-year event-free survival (EFS) and overall survival (OS) rates for the transplantation group and the nontransplantation group were 65.5% vs. 41.3% (p=0.023) and 77.1% vs. 57.9% (p=0.03), respectively. There was no difference in the distribution of baseline clinical case characteristics between the single transplantation group and the tandem transplantation group (p>0.05), and there was no significant difference in EFS and OS between the two groups (p>0.05). Conclusion: Based on this pretreatment programme, autologous peripheral blood stem cell transplantation is safe and tolerable and significantly improves the prognosis of children in the high-risk group. The value of tandem autologous stem cell transplantation is worthy of further discussion, which should consider various aspects such as the transplantation medication regimen and the patient's state.
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spelling pubmed-95538612022-10-12 Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma Yan, Jin Jie, Li Jiaxing, Yang Yanna, Cao Zhanglin, Li Zhongyuan, Li Daowei, Wang Guangzong, Zhao Benfu, Zhong Jie, Yan Qiang, Zhao Int J Med Sci Research Paper Objective: This study aimed to analyze the efficacy of autologous peripheral blood stem cell transplantation for high-risk neuroblastoma in China. Methods: The data of 90 high-risk neuroblastoma patients treated with the CCCG-NB 2015 regimen were reviewed. The baseline clinicopathological characteristics and prognosis were analyzed and compared. In addition, the prognoses of tandem autologous stem cell transplantation and single autologous stem cell transplantation groups were compared. Results: The results of survival analysis showed that autologous peripheral blood stem cell transplantation based on this pretreatment regimen significantly improved the prognosis of children in the high-risk group. The 3-year event-free survival (EFS) and overall survival (OS) rates for the transplantation group and the nontransplantation group were 65.5% vs. 41.3% (p=0.023) and 77.1% vs. 57.9% (p=0.03), respectively. There was no difference in the distribution of baseline clinical case characteristics between the single transplantation group and the tandem transplantation group (p>0.05), and there was no significant difference in EFS and OS between the two groups (p>0.05). Conclusion: Based on this pretreatment programme, autologous peripheral blood stem cell transplantation is safe and tolerable and significantly improves the prognosis of children in the high-risk group. The value of tandem autologous stem cell transplantation is worthy of further discussion, which should consider various aspects such as the transplantation medication regimen and the patient's state. Ivyspring International Publisher 2022-09-25 /pmc/articles/PMC9553861/ /pubmed/36237985 http://dx.doi.org/10.7150/ijms.76305 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Yan, Jin
Jie, Li
Jiaxing, Yang
Yanna, Cao
Zhanglin, Li
Zhongyuan, Li
Daowei, Wang
Guangzong, Zhao
Benfu, Zhong
Jie, Yan
Qiang, Zhao
Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
title Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
title_full Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
title_fullStr Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
title_full_unstemmed Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
title_short Analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
title_sort analysis of the efficacy of autologous peripheral blood stem cell transplantation in high-risk neuroblastoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553861/
https://www.ncbi.nlm.nih.gov/pubmed/36237985
http://dx.doi.org/10.7150/ijms.76305
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