ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis

BACKGROUND: Desmoplastic stroma, a feature of pancreatic ductal adenocarcinoma (PDAC), contains abundant activated pancreatic stellate cells (PSCs). How PSCs promote PDAC progression remains incompletely understood. METHODS: Effect of epithelium-specific E-twenty six factor 3 (ESE3)-positive PSCs on...

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Detalles Bibliográficos
Autores principales: Zhao, Tiansuo, Xiao, Di, Jin, Fanjie, Sun, Xugang, Yu, Jie, Wang, Hongwei, Liu, Jing, Cai, Wenrun, Huang, Chongbiao, Wang, Xiuchao, Gao, Song, Liu, Zhe, Yang, Shengyu, Gao, Chuntao, Hao, Jihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553871/
https://www.ncbi.nlm.nih.gov/pubmed/35986089
http://dx.doi.org/10.1038/s41416-022-01927-y

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