mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation

The mouse vaginal epithelium cyclically exhibits cell proliferation and differentiation in response to estrogen. Estrogen acts as an activator of mTOR signaling but its role in vaginal epithelial homeostasis is unknown. We analyzed reproductive tract-specific Rptor or Rictor conditional knockout mic...

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Detalles Bibliográficos
Autores principales: Wan, Shuo, Sun, Yadong, Fu, Jiamin, Song, Hongrui, Xiao, Zhiqiang, Yang, Quanli, Wang, Sanfeng, Yu, Gongwang, Feng, Peiran, Lv, Wenkai, Luo, Liang, Guan, Zerong, Liu, Feng, Zhou, Qinghua, Yin, Zhinan, Yang, Meixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553898/
https://www.ncbi.nlm.nih.gov/pubmed/36220823
http://dx.doi.org/10.1038/s41419-022-05293-8

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