Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor for postnatal heart development. Through multiomics screening, we found that the expression...

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Detalles Bibliográficos
Autores principales: Chong, Danyang, Gu, Yayun, Zhang, Tongyu, Xu, Yu, Bu, Dandan, Chen, Zhong, Xu, Na, Li, Liangkui, Zhu, Xiyu, Wang, Haiquan, Li, Yangqing, Zheng, Feng, Wang, Dongjin, Li, Peng, Xu, Li, Hu, Zhibin, Li, Chaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553951/
https://www.ncbi.nlm.nih.gov/pubmed/36220812
http://dx.doi.org/10.1038/s41421-022-00447-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553951/
https://www.ncbi.nlm.nih.gov/pubmed/36220812
http://dx.doi.org/10.1038/s41421-022-00447-6

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