Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals

The present cross-sectional study aims to understand the fungal community composition of the nasopharyngeal region of SARS-CoV-2 infected individuals and how the infection influences the mycobiome therein. The infection significantly (p < 0.05) influenced the alpha diversity. Interestingly, a hig...

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Autores principales: Gupta, Abhishek, Bhanushali, Shivang, Karyakarte, Rajesh, Joshi, Suvarna, Das, Rashmita, Shouche, Yogesh, Sharma, Avinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institut Pasteur. Published by Elsevier Masson SAS. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553963/
https://www.ncbi.nlm.nih.gov/pubmed/36241143
http://dx.doi.org/10.1016/j.micinf.2022.105059
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author Gupta, Abhishek
Bhanushali, Shivang
Karyakarte, Rajesh
Joshi, Suvarna
Das, Rashmita
Shouche, Yogesh
Sharma, Avinash
author_facet Gupta, Abhishek
Bhanushali, Shivang
Karyakarte, Rajesh
Joshi, Suvarna
Das, Rashmita
Shouche, Yogesh
Sharma, Avinash
author_sort Gupta, Abhishek
collection PubMed
description The present cross-sectional study aims to understand the fungal community composition of the nasopharyngeal region of SARS-CoV-2 infected individuals and how the infection influences the mycobiome therein. The infection significantly (p < 0.05) influenced the alpha diversity. Interestingly, a higher abundance of Cladosporium and Alternaria was noted in the infected individuals and inter-individual variation in mycobiome composition was well supported by beta dispersion analysis (p < 0.05). Moreover, decrease in Aspergillus abundance was observed in infected patients across the four age groups. This study provides insight into the alteration in mycobiome during the viral disease progression and demands continuous investigation to monitor fungal infections.
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spelling pubmed-95539632022-10-12 Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals Gupta, Abhishek Bhanushali, Shivang Karyakarte, Rajesh Joshi, Suvarna Das, Rashmita Shouche, Yogesh Sharma, Avinash Microbes Infect Short Communication The present cross-sectional study aims to understand the fungal community composition of the nasopharyngeal region of SARS-CoV-2 infected individuals and how the infection influences the mycobiome therein. The infection significantly (p < 0.05) influenced the alpha diversity. Interestingly, a higher abundance of Cladosporium and Alternaria was noted in the infected individuals and inter-individual variation in mycobiome composition was well supported by beta dispersion analysis (p < 0.05). Moreover, decrease in Aspergillus abundance was observed in infected patients across the four age groups. This study provides insight into the alteration in mycobiome during the viral disease progression and demands continuous investigation to monitor fungal infections. Institut Pasteur. Published by Elsevier Masson SAS. 2023 2022-10-12 /pmc/articles/PMC9553963/ /pubmed/36241143 http://dx.doi.org/10.1016/j.micinf.2022.105059 Text en © 2022 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Gupta, Abhishek
Bhanushali, Shivang
Karyakarte, Rajesh
Joshi, Suvarna
Das, Rashmita
Shouche, Yogesh
Sharma, Avinash
Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals
title Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals
title_full Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals
title_fullStr Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals
title_full_unstemmed Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals
title_short Mycobiome profiling of nasopharyngeal region of SARS-CoV-2 infected individuals
title_sort mycobiome profiling of nasopharyngeal region of sars-cov-2 infected individuals
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553963/
https://www.ncbi.nlm.nih.gov/pubmed/36241143
http://dx.doi.org/10.1016/j.micinf.2022.105059
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