The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis

Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (N...

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Autores principales: Sang, Lei, Wang, Xingshun, Bai, Weiyu, Shen, Junling, Zeng, Yong, Sun, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554155/
https://www.ncbi.nlm.nih.gov/pubmed/36249028
http://dx.doi.org/10.3389/fonc.2022.1011230
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author Sang, Lei
Wang, Xingshun
Bai, Weiyu
Shen, Junling
Zeng, Yong
Sun, Jianwei
author_facet Sang, Lei
Wang, Xingshun
Bai, Weiyu
Shen, Junling
Zeng, Yong
Sun, Jianwei
author_sort Sang, Lei
collection PubMed
description Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases.
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spelling pubmed-95541552022-10-13 The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis Sang, Lei Wang, Xingshun Bai, Weiyu Shen, Junling Zeng, Yong Sun, Jianwei Front Oncol Oncology Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases. Frontiers Media S.A. 2022-09-28 /pmc/articles/PMC9554155/ /pubmed/36249028 http://dx.doi.org/10.3389/fonc.2022.1011230 Text en Copyright © 2022 Sang, Wang, Bai, Shen, Zeng and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sang, Lei
Wang, Xingshun
Bai, Weiyu
Shen, Junling
Zeng, Yong
Sun, Jianwei
The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
title The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
title_full The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
title_fullStr The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
title_full_unstemmed The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
title_short The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
title_sort role of hepatocyte nuclear factor 4α (hnf4α) in tumorigenesis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554155/
https://www.ncbi.nlm.nih.gov/pubmed/36249028
http://dx.doi.org/10.3389/fonc.2022.1011230
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