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Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents

Limited evidence is available regarding the association of methyl donor nutrients and adolescents’ metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross-sectiona...

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Autores principales: Poursalehi, Donya, Lotfi, Keyhan, Mirzaei, Saeideh, Asadi, Ali, Akhlaghi, Masoumeh, Saneei, Parvane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554193/
https://www.ncbi.nlm.nih.gov/pubmed/36220981
http://dx.doi.org/10.1038/s41598-022-21602-9
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author Poursalehi, Donya
Lotfi, Keyhan
Mirzaei, Saeideh
Asadi, Ali
Akhlaghi, Masoumeh
Saneei, Parvane
author_facet Poursalehi, Donya
Lotfi, Keyhan
Mirzaei, Saeideh
Asadi, Ali
Akhlaghi, Masoumeh
Saneei, Parvane
author_sort Poursalehi, Donya
collection PubMed
description Limited evidence is available regarding the association of methyl donor nutrients and adolescents’ metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross-sectional study, 203 overweight/obese adolescents were included, using a multistage cluster random-sampling method. Dietary intakes were assessed by a validated food frequency questionnaire. Methyl donor nutrient score (MDNS) was constructed based on deciles of vitamins B2, B6, B9, B12, methionine, choline and betaine. Glycemic profile, lipid profile, blood pressure and anthropometric indices were collected. Participants were classified as metabolically healthy obese or unhealthy obese (MUO) based on International Diabetes Federation (IDF) and IDF/Homeostasis Model Assessment Insulin Resistance (HOMA-IR) definitions. Mean age of adolescents was 13.98 [Formula: see text] 1.61 y and 50.2% of them was girls. After controlling all of the confounders, individuals in the top tertile of MDNS, had lower odds of MUO (OR 0.36; 95% CI 0.13–0.95) according to IFD criteria. Considering IDF/HOMA-IR criteria, an inverse marginally significant association was observed between the highest tertile of MDNS and odds of MUO (OR 0.36; 95% CI 0.12–1.02) in the fully-adjusted model. Furthermore, significant inverse association was found between each unit increase in MDNS and odds of MUO based on IDF criteria, but not for IDF/HOMA-IR definition. We found that overweight/obese adolescents with higher dietary intakes of methyl donor nutrients were less likely to be metabolically unhealthy. Further studies are needed to confirm the findings.
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spelling pubmed-95541932022-10-13 Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents Poursalehi, Donya Lotfi, Keyhan Mirzaei, Saeideh Asadi, Ali Akhlaghi, Masoumeh Saneei, Parvane Sci Rep Article Limited evidence is available regarding the association of methyl donor nutrients and adolescents’ metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross-sectional study, 203 overweight/obese adolescents were included, using a multistage cluster random-sampling method. Dietary intakes were assessed by a validated food frequency questionnaire. Methyl donor nutrient score (MDNS) was constructed based on deciles of vitamins B2, B6, B9, B12, methionine, choline and betaine. Glycemic profile, lipid profile, blood pressure and anthropometric indices were collected. Participants were classified as metabolically healthy obese or unhealthy obese (MUO) based on International Diabetes Federation (IDF) and IDF/Homeostasis Model Assessment Insulin Resistance (HOMA-IR) definitions. Mean age of adolescents was 13.98 [Formula: see text] 1.61 y and 50.2% of them was girls. After controlling all of the confounders, individuals in the top tertile of MDNS, had lower odds of MUO (OR 0.36; 95% CI 0.13–0.95) according to IFD criteria. Considering IDF/HOMA-IR criteria, an inverse marginally significant association was observed between the highest tertile of MDNS and odds of MUO (OR 0.36; 95% CI 0.12–1.02) in the fully-adjusted model. Furthermore, significant inverse association was found between each unit increase in MDNS and odds of MUO based on IDF criteria, but not for IDF/HOMA-IR definition. We found that overweight/obese adolescents with higher dietary intakes of methyl donor nutrients were less likely to be metabolically unhealthy. Further studies are needed to confirm the findings. Nature Publishing Group UK 2022-10-11 /pmc/articles/PMC9554193/ /pubmed/36220981 http://dx.doi.org/10.1038/s41598-022-21602-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Poursalehi, Donya
Lotfi, Keyhan
Mirzaei, Saeideh
Asadi, Ali
Akhlaghi, Masoumeh
Saneei, Parvane
Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
title Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
title_full Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
title_fullStr Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
title_full_unstemmed Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
title_short Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
title_sort association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554193/
https://www.ncbi.nlm.nih.gov/pubmed/36220981
http://dx.doi.org/10.1038/s41598-022-21602-9
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