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Measurement of the Macular Hole Diameter by En Face Slab Optical Coherence Tomography Reflectance Imaging

PURPOSE: To evaluate the repeatability of macular hole (MH) diameter measurement on en face slab optical coherence tomography (OCT) reflectance images and assess its potential to predict visual acuity (VA). METHODS: We enrolled 27 eyes with full-thickness MHs in this study. Preoperative en face slab...

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Detalles Bibliográficos
Autores principales: Uechi, Yuna, Nakamura, Kentaro, Shinozuka, Masato, Kawasaki, Shohei, Okawa, Kazuyoshi, Inoue, Tatsuya, Asaoka, Ryo, Maruyama-Inoue, Maiko, Yanagi, Yasuo, Kadonosono, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554266/
https://www.ncbi.nlm.nih.gov/pubmed/36201199
http://dx.doi.org/10.1167/tvst.11.10.13
Descripción
Sumario:PURPOSE: To evaluate the repeatability of macular hole (MH) diameter measurement on en face slab optical coherence tomography (OCT) reflectance images and assess its potential to predict visual acuity (VA). METHODS: We enrolled 27 eyes with full-thickness MHs in this study. Preoperative en face slab OCT reflectance images were obtained. Image binarization, ellipse approximation, and uncorrected measurement of minimum diameter, min(ef_uc), and maximum diameter, max(ef_uc), were performed using ImageJ. In addition, magnification-corrected diameters were calculated as min(ef) and max(ef) using the Littman and modified Bennett formulas. Spectral-domain OCT horizontal images were used as the conventional method for the analysis: min(conv) and max(conv). The inter-rater reliability of the method was evaluated by calculating the intraclass correlation coefficient (ICC). The following relationships were analyzed: (1) between logMAR VA and min(ef_uc), min(ef), and min(conv); and (2) between logMAR VA and max(ef_uc), max(ef), and max(conv). RESULTS: The min(ef) and max(ef) values were 439.4 ± 240.5 µm and 720.7 ± 346.1 µm, respectively. The ICC values were 0.985 and 0.999 for min(ef) and max(ef), and 0.885 and 0.909 for min(conv) and max(conv), respectively. Multivariate analysis suggested that min(ef), but not min(ef_uc) or min(conv), was associated with pre- and postoperative logMAR VA. Furthermore, max(ef), but not max(ef_uc) or max(conv), was also closely correlated with pre- and postoperative logMAR VA. CONCLUSIONS: The MH diameter measured by our method is highly reproducible and closely associated with VA compared to that measured by the conventional method. TRANSLATIONAL RELEVANCE: The MH diameter measured by this modality might serve as an accurate biomarker to predict visual function in eyes with MH.