Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures

Melanoma is a highly aggressive skin cancer, which, although highly immunogenic, frequently escapes the body’s immune defences. Immune checkpoint inhibitors (ICI), such as anti-PD1, anti-PDL1, and anti-CTLA4 antibodies lead to reactivation of immune pathways, promoting rejection of melanoma. However...

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Detalles Bibliográficos
Autores principales: Hossain, Sultana Mehbuba, Gimenez, Gregory, Stockwell, Peter A., Tsai, Peter, Print, Cristin G., Rys, Janusz, Cybulska-Stopa, Bozena, Ratajska, Magda, Harazin-Lechowska, Agnieszka, Almomani, Suzan, Jackson, Christopher, Chatterjee, Aniruddha, Eccles, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554309/
https://www.ncbi.nlm.nih.gov/pubmed/36248850
http://dx.doi.org/10.3389/fimmu.2022.955063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554309/
https://www.ncbi.nlm.nih.gov/pubmed/36248850
http://dx.doi.org/10.3389/fimmu.2022.955063

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