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Catalytic Antibodies: Design, Expression, and Their Applications in Medicine
Catalytic antibodies made it feasible to develop new catalysts, which had previously been the subject of research. Scientists have discovered natural antibodies that can hydrolyze substrates such as nucleic acids, proteins, and polysaccharides during decades of research, as well as several ways of p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554387/ https://www.ncbi.nlm.nih.gov/pubmed/36222989 http://dx.doi.org/10.1007/s12010-022-04183-1 |
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author | Zhao, Daqun Chen, Jie Hu, Xiaoyue Zhang, Shujun |
author_facet | Zhao, Daqun Chen, Jie Hu, Xiaoyue Zhang, Shujun |
author_sort | Zhao, Daqun |
collection | PubMed |
description | Catalytic antibodies made it feasible to develop new catalysts, which had previously been the subject of research. Scientists have discovered natural antibodies that can hydrolyze substrates such as nucleic acids, proteins, and polysaccharides during decades of research, as well as several ways of producing antibodies with specialized characteristics and catalytic functions. These antibodies are widely used in chemistry, biology, and medicine. Catalytic antibodies can continue to play a role and even fully prevent the emergence of autoimmune disorders, especially in the field of infection and immunity, where the process of its occurrence and development often takes a long time. In this work, the development, design and evolution methodologies, and the expression systems and applications of catalytic antibodies, are discussed. Trial registration: not applicable. |
format | Online Article Text |
id | pubmed-9554387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-95543872022-10-12 Catalytic Antibodies: Design, Expression, and Their Applications in Medicine Zhao, Daqun Chen, Jie Hu, Xiaoyue Zhang, Shujun Appl Biochem Biotechnol Review Article Catalytic antibodies made it feasible to develop new catalysts, which had previously been the subject of research. Scientists have discovered natural antibodies that can hydrolyze substrates such as nucleic acids, proteins, and polysaccharides during decades of research, as well as several ways of producing antibodies with specialized characteristics and catalytic functions. These antibodies are widely used in chemistry, biology, and medicine. Catalytic antibodies can continue to play a role and even fully prevent the emergence of autoimmune disorders, especially in the field of infection and immunity, where the process of its occurrence and development often takes a long time. In this work, the development, design and evolution methodologies, and the expression systems and applications of catalytic antibodies, are discussed. Trial registration: not applicable. Springer US 2022-10-12 2023 /pmc/articles/PMC9554387/ /pubmed/36222989 http://dx.doi.org/10.1007/s12010-022-04183-1 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Zhao, Daqun Chen, Jie Hu, Xiaoyue Zhang, Shujun Catalytic Antibodies: Design, Expression, and Their Applications in Medicine |
title | Catalytic Antibodies: Design, Expression, and Their Applications in Medicine |
title_full | Catalytic Antibodies: Design, Expression, and Their Applications in Medicine |
title_fullStr | Catalytic Antibodies: Design, Expression, and Their Applications in Medicine |
title_full_unstemmed | Catalytic Antibodies: Design, Expression, and Their Applications in Medicine |
title_short | Catalytic Antibodies: Design, Expression, and Their Applications in Medicine |
title_sort | catalytic antibodies: design, expression, and their applications in medicine |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554387/ https://www.ncbi.nlm.nih.gov/pubmed/36222989 http://dx.doi.org/10.1007/s12010-022-04183-1 |
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