Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO(3) (−))-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely essential in sperm for reproduction. For thi...

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Detalles Bibliográficos
Autores principales: Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W., Meinke, Peter T., Levin, Lonny R., Buck, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554468/
https://www.ncbi.nlm.nih.gov/pubmed/36246105
http://dx.doi.org/10.3389/fphys.2022.1013845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554468/
https://www.ncbi.nlm.nih.gov/pubmed/36246105
http://dx.doi.org/10.3389/fphys.2022.1013845

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