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GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis

Glucose-6-phosphate isomerase (GPI) plays an important part in gluconeogenesis and glycolysis through the interconversion of d-glucose-6-phosphate and d-fructose-6-phosphate, and its clinical significance still remains unclear in breast cancer (BRCA). We analyzed the expressions of GPI in BRCA patie...

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Autores principales: Zeng, Jie, Yi, Jianing, Tan, Siyi, Zeng, Yuanjun, Zou, Lianhong, Zhang, Chaojie, Liu, Luyao, Yi, Pingyong, Fan, Peizhi, Yu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554491/
https://www.ncbi.nlm.nih.gov/pubmed/36246907
http://dx.doi.org/10.3389/fendo.2022.995972
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author Zeng, Jie
Yi, Jianing
Tan, Siyi
Zeng, Yuanjun
Zou, Lianhong
Zhang, Chaojie
Liu, Luyao
Yi, Pingyong
Fan, Peizhi
Yu, Jie
author_facet Zeng, Jie
Yi, Jianing
Tan, Siyi
Zeng, Yuanjun
Zou, Lianhong
Zhang, Chaojie
Liu, Luyao
Yi, Pingyong
Fan, Peizhi
Yu, Jie
author_sort Zeng, Jie
collection PubMed
description Glucose-6-phosphate isomerase (GPI) plays an important part in gluconeogenesis and glycolysis through the interconversion of d-glucose-6-phosphate and d-fructose-6-phosphate, and its clinical significance still remains unclear in breast cancer (BRCA). We analyzed the expressions of GPI in BRCA patients to determine prognostic values. Our results showed that the expression levels of GPI were upregulated in BRCA patients, and a high GPI expression is correlated with poor overall survival (OS) in BRCA. At the same time, a high GPI expression is correlated with poor clinicopathological characteristics, such as stage III, over 60 years old, N3, HER2 negative, and estrogen receptor (ER) positive. Further analysis of the influence of GPI on the prognosis of BRCA suggested that 50 genes and 10 proteins were positively correlated with GPI, and these genes and proteins were mainly involved in cell cycle signaling pathways. In addition, in this study, we observed that GPI was closely related to N (6)-methyladenosine (m6A) RNA methylation modification and immune cell infiltration and ferroptosis-related gene expression in BRCA, and there was a difference in m6A RNA methylation alterations, immune cell infiltration, and ferroptosis-related gene expression between the high GPI expression group and the low GPI expression group. Finally, we found that GPI in BRCA had 2.6% gene alterations, and BRCA patients with gene alteration of GPI had a poor prognosis in disease-free survival (DFS). Altogether, our work strongly suggested that GPI may serve as a new prognostic biomarker for BRCA patients.
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spelling pubmed-95544912022-10-13 GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis Zeng, Jie Yi, Jianing Tan, Siyi Zeng, Yuanjun Zou, Lianhong Zhang, Chaojie Liu, Luyao Yi, Pingyong Fan, Peizhi Yu, Jie Front Endocrinol (Lausanne) Endocrinology Glucose-6-phosphate isomerase (GPI) plays an important part in gluconeogenesis and glycolysis through the interconversion of d-glucose-6-phosphate and d-fructose-6-phosphate, and its clinical significance still remains unclear in breast cancer (BRCA). We analyzed the expressions of GPI in BRCA patients to determine prognostic values. Our results showed that the expression levels of GPI were upregulated in BRCA patients, and a high GPI expression is correlated with poor overall survival (OS) in BRCA. At the same time, a high GPI expression is correlated with poor clinicopathological characteristics, such as stage III, over 60 years old, N3, HER2 negative, and estrogen receptor (ER) positive. Further analysis of the influence of GPI on the prognosis of BRCA suggested that 50 genes and 10 proteins were positively correlated with GPI, and these genes and proteins were mainly involved in cell cycle signaling pathways. In addition, in this study, we observed that GPI was closely related to N (6)-methyladenosine (m6A) RNA methylation modification and immune cell infiltration and ferroptosis-related gene expression in BRCA, and there was a difference in m6A RNA methylation alterations, immune cell infiltration, and ferroptosis-related gene expression between the high GPI expression group and the low GPI expression group. Finally, we found that GPI in BRCA had 2.6% gene alterations, and BRCA patients with gene alteration of GPI had a poor prognosis in disease-free survival (DFS). Altogether, our work strongly suggested that GPI may serve as a new prognostic biomarker for BRCA patients. Frontiers Media S.A. 2022-09-28 /pmc/articles/PMC9554491/ /pubmed/36246907 http://dx.doi.org/10.3389/fendo.2022.995972 Text en Copyright © 2022 Zeng, Yi, Tan, Zeng, Zou, Zhang, Liu, Yi, Fan and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zeng, Jie
Yi, Jianing
Tan, Siyi
Zeng, Yuanjun
Zou, Lianhong
Zhang, Chaojie
Liu, Luyao
Yi, Pingyong
Fan, Peizhi
Yu, Jie
GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
title GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
title_full GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
title_fullStr GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
title_full_unstemmed GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
title_short GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
title_sort gpi: an indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554491/
https://www.ncbi.nlm.nih.gov/pubmed/36246907
http://dx.doi.org/10.3389/fendo.2022.995972
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